Phosphorylation by mTORC1 stablizes Skp2 and regulates its oncogenic function in gastric cancer

被引：0
|
作者：
Qirong Geng
Jianjun Liu
Zhaohui Gong
Shangxiang Chen
Shuai Chen
Xiaoxing Li
Yue Lu
Xiaofeng Zhu
Hui-kuan Lin
Dazhi Xu
机构：
[1] Collaborative Innovation Center for Cancer Medicine,State Key Laboratory of Oncology in South China
[2] Sun Yat-sen University Cancer Center,Department of Hematology Oncology
[3] Sun Yat-sen University Cancer Center,Department of Gastric Surgery
[4] Ningbo University School of Medicine,Institute of Biochemistry and Molecular Biology
[5] Ningbo,Department of Molecular and Cellular Oncology, M.D. Anderson Cancer Center
[6] The University of Texas,undefined
来源：
Molecular Cancer | / 16卷
关键词：
mTORC1; Phosphorylation; Skp2; Gastric cancer;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [21] Constitutively Active Rheb Regulates Nuclear mTORC1 Activity and Function
    Zhong, Yanghao
    Zhou, Xin
    Guan, Kun-Liang
    Zhang, Jin
    FASEB JOURNAL, 2020, 34
  • [22] Skp2: A critical molecule for ubiquitination and its role in cancer
    Feng, Tianyang
    Wang, Ping
    Zhang, Xiling
    LIFE SCIENCES, 2024, 338
  • [23] Rapamycin inhibits mSin1 phosphorylation independently of mTORC1 and mTORC2
    Luo, Yan
    Liu, Lei
    Wu, Yang
    Singh, Karnika
    Su, Bing
    Zhang, Nan
    Liu, Xiaowei
    Shen, Yangmei
    Huang, Shile
    ONCOTARGET, 2015, 6 (06) : 4286 - 4298
  • [24] β-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway
    Marwarha, Gurdeep
    Dasari, Bhanu
    Prabhakara, Jaya Prasanthi Rantham
    Schommer, Jared
    Ghribi, Othman
    JOURNAL OF NEUROCHEMISTRY, 2010, 115 (02) : 373 - 384
  • [25] mTORC1 and mTORC2 Regulates Placental Amino Acid Transporters.
    Rosario, Fredrick J.
    Powell, Theresa L.
    Jansson, Thomas
    REPRODUCTIVE SCIENCES, 2010, 17 (03) : 259A - 259A
  • [26] Roles of mTORC1 and mTORC2 in controlling γδ 1 and γδ 17 differentiation and function
    Yang, Q.
    Liu, X.
    Liu, Q.
    Hao, J.
    Yin, Z.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 365 - 366
  • [27] CDK4 Regulates Lysosomal Function and mTORC1 Activation to Promote Cancer Cell Survival
    Martinez-Carreres, Laia
    Puyal, Julien
    Leal-Esteban, Lucia C.
    Orpinell, Meritxell
    Castillo-Armengol, Judit
    Giralt, Albert
    Dergai, Oleksandr
    Moret, Catherine
    Barquissau, Valentin
    Nasrallah, Anita
    Pabois, Angelique
    Zhang, Lianjun
    Romero, Pedro
    Lopez-Mejia, Isabel C.
    Fajas, Lluis
    CANCER RESEARCH, 2019, 79 (20) : 5245 - 5259
  • [28] Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated Raptor phosphorylation
    Carriere, Audrey
    Cargnello, Marie
    Julien, Louis-Andre
    Gao, Huanhuan
    Bonneil, Eric
    Thibault, Pierre
    Roux, Philippe P.
    CURRENT BIOLOGY, 2008, 18 (17) : 1269 - 1277
  • [29] Regulation of Skp2 Expression and Activity and Its Role in Cancer Progression
    Chan, Chia-Hsin
    Lee, Szu-Wei
    Wang, Jing
    Lin, Hui-Kuan
    THESCIENTIFICWORLDJOURNAL, 2010, 10 : 1001 - 1015
  • [30] Notch and mTORC1 regulate human gastric stem cell function during normal tissue homeostasis and gastric cancer
    Demitrack, Elise S.
    Gifford, Gail B.
    Wong, Gabriela
    Samuelson, Linda C.
    CANCER RESEARCH, 2016, 76
12345