Preparation of Recombinant Atoxic Form of Exotoxin A from Pseudomonas Aeruginosa

被引:0
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作者
A. A. Kaloshin
M. A. Isakov
N. A. Mikhailova
Ju. V. Vertiev
机构
[1] Russian Academy of Medical Sciences,I. I. Mechnikov Institute of Vaccines and Sera
关键词
exotoxin A; antitoxin; toxA gene;
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摘要
Nucleotide sequences encoding full-length protein of Pseudomonas aeruginosa exotoxin A and its atoxic form were cloned and expressed in Escherichia coli cells. Purified recombinant exotoxin and immune rabbit sera protected mice from exotoxin A.
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页码:346 / 350
页数:4
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