The establishment of neuron-specific enolase reference interval for the healthy population in southwest China
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作者:
Qiang Miao
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机构:Department of Laboratory Medicine/ Research Center of Clinical Laboratory Medicine,
Qiang Miao
Bei Cai
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机构:Department of Laboratory Medicine/ Research Center of Clinical Laboratory Medicine,
Bei Cai
Xuedan Gao
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机构:Department of Laboratory Medicine/ Research Center of Clinical Laboratory Medicine,
Xuedan Gao
Zhenzhen Su
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机构:Department of Laboratory Medicine/ Research Center of Clinical Laboratory Medicine,
Zhenzhen Su
Junlong Zhang
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机构:Department of Laboratory Medicine/ Research Center of Clinical Laboratory Medicine,
Junlong Zhang
机构:
[1] Department of Laboratory Medicine/ Research Center of Clinical Laboratory Medicine,
[2] West China Hospital of Sichuan University,undefined
来源:
Scientific Reports
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10卷
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摘要:
To investigate and establish a reference interval (RI) of neuron-specific enolase (NSE) in southwest China’s healthy population by using the laboratory information system database. A total of 86957 periodic health examination individuals of the medical examination center in West China Hospital from 2016 to 2018 were included in the study. We used the Box-Cox conversion combined with the Tukey method to normalize the data and eliminate the outliers, and the normal distribution method and the nonparametric method to estimate the 95% distribution RI. The NSE 95% distribution RI we established in healthy populations in southwest China through normal distribution and nonparametric method were 0–19.64 ng/ml and 0–20.46 ng/ml, respectively. The obtained RIs verification conformed to the standard and was significantly different from the reagent instruction(P < 0.05). The RI established by the nonparametric method was superior to the RI of the normal distribution method and reagent instruction(P < 0.05). We initially established an NSE RI that was suitable for the healthy southwest China population. The Box-Cox conversion combined with the Tukey method and nonparametric method is a reliable and straightforward indirect method for reference interval acquisition, which is suitable for the promotion and application of clinical laboratory.
机构:
Baskent Univ, Fac Med, Div Pediat Neurol, Dept Pediat, TR-06490 Ankara, TurkeyBaskent Univ, Fac Med, Div Pediat Neurol, Dept Pediat, TR-06490 Ankara, Turkey
Azapagasi, Ebru
Alehan, Fusun
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Baskent Univ, Fac Med, Div Pediat Neurol, Dept Pediat, TR-06490 Ankara, TurkeyBaskent Univ, Fac Med, Div Pediat Neurol, Dept Pediat, TR-06490 Ankara, Turkey
Alehan, Fusun
Saygi, Semra
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Baskent Univ, Fac Med, Div Pediat Neurol, Dept Pediat, TR-06490 Ankara, TurkeyBaskent Univ, Fac Med, Div Pediat Neurol, Dept Pediat, TR-06490 Ankara, Turkey
Saygi, Semra
Bayraktar, Nilufer
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机构:
Baskent Univ, Fac Med, Dept Biochem, TR-06490 Ankara, TurkeyBaskent Univ, Fac Med, Div Pediat Neurol, Dept Pediat, TR-06490 Ankara, Turkey
机构:
Fujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R China
Huang, Hong-Bo
Huang, Jun-Ling
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Fujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R China
Huang, Jun-Ling
Xu, Xiao-Ting
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Fujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R China
Xu, Xiao-Ting
Huang, Kun-Bo
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Fujian Med Univ, Quanzhou Hosp 1, Dept Clin Lab, Quanzhou 362000, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R China
Huang, Kun-Bo
Lin, Yi-Jian
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Fujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R China
Lin, Yi-Jian
Lin, Jie-Bin
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机构:
Infect Dis Hosp Quanzhou, Dept Internal Med, Quanzhou 362000, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R China
Lin, Jie-Bin
Zhuang, Xi-Bin
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Fujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R ChinaFujian Med Univ, Quanzhou Hosp 1, Dept Pulm & Crit Care Med, 248-252 East St, Quanzhou 362000, Fujian, Peoples R China
机构:
Univ Washington, Dept Pediat, RD-20, Seattle, WA 98195 USA
Childrens Orthoped Hosp, Seattle, WA USA
Univ Washington, Med Ctr, Seattle, WA 98195 USAUniv Washington, Dept Pediat, RD-20, Seattle, WA 98195 USA
Chen, Shi-Han
Omenn, Gilbert S.
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Univ Washington, Sch Publ Hlth, Seattle, WA 98195 USAUniv Washington, Dept Pediat, RD-20, Seattle, WA 98195 USA