Synthesis and pharmacological activity of tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfonylacetate (sulfacetamine)

被引：0
|
作者：
A. N. Mirskova
S. N. Adamovich
R. G. Mirskov
机构：
[1] Russian Academy of Sciences,Favorsky State Institute of Chemistry, Siberian Branch
来源：
Pharmaceutical Chemistry Journal | 2012年 / 46卷
关键词：
4-chlorophenylsulfonylacetic acid; -(2-hydroxyethyl)ammonium 4-chlorophenylsulfonylacetate (sulfacetamine); antithrombotic; membrane-stabilizing; antioxidant; hypocholesterolemic; adaptogenic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Methods for the synthesis of 4-chlorophenylsulfonylacetic acid and its tris-(2-hydroxyethyl)ammonium salt (sulfacetamine) were developed. Results of in vitro and in vivo experiments showed that sulfacetamine possessed high antithrombotic, membrane-stabilizing, antioxidant, hypocholesterolemic, and adaptogenic activity with low toxicity to animals.
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页码：392 / 396
页数：4
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