Synthesis and pharmacological activity of tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfonylacetate (sulfacetamine)

被引：0
|
作者：
A. N. Mirskova
S. N. Adamovich
R. G. Mirskov
机构：
[1] Russian Academy of Sciences,Favorsky State Institute of Chemistry, Siberian Branch
来源：
Pharmaceutical Chemistry Journal | 2012年 / 46卷
关键词：
4-chlorophenylsulfonylacetic acid; -(2-hydroxyethyl)ammonium 4-chlorophenylsulfonylacetate (sulfacetamine); antithrombotic; membrane-stabilizing; antioxidant; hypocholesterolemic; adaptogenic activity;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Methods for the synthesis of 4-chlorophenylsulfonylacetic acid and its tris-(2-hydroxyethyl)ammonium salt (sulfacetamine) were developed. Results of in vitro and in vivo experiments showed that sulfacetamine possessed high antithrombotic, membrane-stabilizing, antioxidant, hypocholesterolemic, and adaptogenic activity with low toxicity to animals.
引用
收藏
页码：392 / 396
页数：4
相关论文
共 50 条
  • [1] Synthesis and pharmacological activity of tris-(2-hydroxyethyl)ammonium 4-chlorophenylsulfonylacetate (sulfacetamine)
    Mirskova, A. N.
    Adamovich, S. N.
    Mirskov, R. G.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2012, 46 (07) : 392 - 396
  • [2] Synthesis and Pharmacological Activity of Tris(2-hydroxyethyl)ammonium 4-Chlorophenylsulfonylacetate
    Adamovich, S. N.
    Oborina, E. N.
    Mirskova, A. N.
    RUSSIAN JOURNAL OF APPLIED CHEMISTRY, 2018, 91 (04) : 701 - 705
  • [3] Synthesis and Pharmacological Activity of Tris(2-hydroxyethyl)ammonium 4-Chlorophenylsulfonylacetate
    S. N. Adamovich
    E. N. Oborina
    A. N. Mirskova
    Russian Journal of Applied Chemistry, 2018, 91 : 701 - 705
  • [4] Aroxyprotatranes: Aroxy derivatives of tris-(2-hydroxyethyl)ammonium
    Voronkov, M. G.
    Adamovich, S. N.
    Ushakov, I. A.
    RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2014, 84 (02) : 340 - 342
  • [5] Aroxyprotatranes: Aroxy derivatives of tris-(2-hydroxyethyl)ammonium
    M. G. Voronkov
    S. N. Adamovich
    I. A. Ushakov
    Russian Journal of General Chemistry, 2014, 84 : 340 - 342
  • [6] Carcinostatic and protectoadaptation activity of tris-(2-hydroxyethyl)ammonium slats of arylheteroacetic acids
    Voronkov, M.G.
    Mirskova, A.N.
    Levskovskaya, G.G.
    Doklady Akademii Nauk, 2002, 386 (03) : 411 - 415
  • [7] Pharmacological activity and clinical effects of trecrezan and other tris-(2-hydroxyethyl)ammonium salts of arylheteroacetic acids (A review)
    Voronkov M.G.
    Kolesnikova O.P.
    Rasulov M.M.
    Mirskova A.N.
    Pharmaceutical Chemistry Journal, 2007, 41 (5) : 244 - 248
  • [8] TRIS-(2-HYDROXYETHYL) ISOCYANURATE
    SAYIGH, AA
    ULRICH, H
    JOURNAL OF THE CHEMICAL SOCIETY, 1961, (JUL): : 3148 - &
  • [9] Molecular and crystal structure of tris-(2-hydroxyethyl)ammonium 4-chlorophenoxy acetate
    S. V. Loginov
    A. M. Abramkin
    V. B. Rybakov
    V. D. Sheludyakov
    P. A. Storozhenko
    Crystallography Reports, 2012, 57 : 521 - 523
  • [10] Molecular and crystal structure of tris-(2-hydroxyethyl)ammonium 4-chlorophenoxy acetate
    Loginov, S. V.
    Abramkin, A. M.
    Rybakov, V. B.
    Sheludyakov, V. D.
    Storozhenko, P. A.
    CRYSTALLOGRAPHY REPORTS, 2012, 57 (04) : 521 - 523
12345