Analysis of autism susceptibility gene loci on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q in Finnish multiplex families

被引：0
|
作者：
M Auranen
T Nieminen
S Majuri
R Vanhala
L Peltonen
I Järvelä
机构：
[1] National Public Health Institute,Department of Human Molecular Genetics
[2] University of Helsinki,Department of Medical Genetics
[3] Unit of Child Neurology,Department of Human Genetics
[4] Hospital for Children and Adolescents,undefined
[5] University of Helsinki,undefined
[6] Outpatient Center for Developmental Disorders,undefined
[7] Vaalijala Institute,undefined
[8] UCLA School of Medicine,undefined
来源：
Molecular Psychiatry | 2000年 / 5卷
关键词：
genetic analysis; sib-pair analysis; isolated population; susceptibility genes;
D O I：
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中图分类号：
学科分类号：
摘要：
The role of genetic factors in the etiology of the autistic spectrum of disorders has clearly been demonstrated. Ten chromosomal regions, on chromosomes 1p, 4p, 6q, 7q, 13q, 15q, 16p, 17q, 19q and 22q have potentially been linked to autism.1–8 We have analyzed these chromosomal regions in a total of 17 multiplex families with autism originating from the isolated Finnish population by pairwise linkage analysis and sib-pair analysis. Mild evidence for putative contribution was found only with the 1p chromosomal region in the susceptibility to autism. Our data suggest that additional gene loci exist for autism which will be detectable in and even restricted to the isolated Finnish population.
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页码：320 / 322
页数：2
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