Synaptotagmin-1 may be a distance regulator acting upstream of SNARE nucleation

被引：0

作者：

Geert van den Bogaart

Shashi Thutupalli

Jelger H Risselada

Karsten Meyenberg

Matthew Holt

Dietmar Riedel

Ulf Diederichsen

Stephan Herminghaus

Helmut Grubmüller

Reinhard Jahn

机构：

[1] Max Planck Institute for Biophysical Chemistry,Department of Neurobiology

[2] Max Planck Institute for Dynamics and Self-Organization,Department of Dynamics of Complex Fluids

[3] Max Planck Institute for Biophysical Chemistry,Department of Theoretical and Computational Biophysics

[4] Institute for Organic and Biomolecular Chemistry,undefined

[5] Georg-August University,undefined

[6] Facility for Electron Microscopy,undefined

[7] Max Planck Institute for Biophysical Chemistry,undefined

来源：

Nature Structural & Molecular Biology | 2011年 / 18卷

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摘要：

Synaptotagmin-1 is known to accelerate membrane fusion during neuronal exocytosis in response to Ca2+, but how it does this is unclear. By probing the activity of synaptotagmin-1 under conditions of low ionic strength, it is now shown that SNARE-mediated fusion is dependent on synaptotagmin-1, which tethers liposomes together but at distances too far for fusion. Ca2+ then induces synaptotagmin-1 to bring the liposomes closer together, allowing fusion to proceed.

引用

页码：805 / 812

页数：7

共 22 条

[21] Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics
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Fortune, Farida
Wheeler, Ann
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[22] Yeast VSM1 Encodes a v-SNARE Binding Protein That May Act as a Negative Regulator of Constitutive Exocytosis (vol 19, pg 4480, 1999)
Lustgarten, Vardit
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MOLECULAR AND CELLULAR BIOLOGY, 2008, 28 (24) : 7534 - 7534

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