Reaction of substituted o-aminophenols with acylpyruvic acid esters and α-ketoglutaric acid. Antibacterial activity of the products

被引：0
|
作者：
Gein V.L. [1 ]
Rassudikhina N.A. [1 ]
Shepelina N.V. [1 ]
Vakhrin M.I. [1 ]
Babushkina E.B. [1 ]
Voronina E.V. [1 ]
机构：
[1] Perm State Pharmaceutical Academy, Perm
来源：
Pharmaceutical Chemistry Journal | 2008年 / 42卷 / 9期
基金：
俄罗斯基础研究基金会;
关键词：
Pyrroli; White Crystalline Compound; Ethacridine Lactate; Perm State Pharmaceutical Academy; Meat Peptone Broth;
D O I：
10.1007/s11094-009-0175-5
中图分类号：
学科分类号：
摘要：
Reaction of methyl esters of acylpyruvic acids with substituted o-aminophenols led to 6(7)-substituted 3-acylmethylene-1,4-benzoxazin-2-ones. Reaction of substituted o-aminophenols with α-ketoglutaric acid led to 6-substituted 3-carbonyl-1,4-benzoxazin-2-ones. The structures of the synthesized compounds were confirmed by IR and NMR spectroscopy and mass spectrometry. The antibacterial activity of the compounds was studied. © 2008 Springer Science+Business Media, Inc.
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页码：529 / 532
页数：3
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