Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF

被引:0
|
作者
Ken-ichi Fujita
Siegfried Janz
机构
[1] National Institutes of Health,Laboratory of Genetics, Center for Cancer Research, National Cancer Institute
[2] Roy J. and Lucille A. Carver College of Medicine,Department of Pathology
[3] University of Iowa,undefined
来源
关键词
Green Fluorescent Protein; Osteoblast Differentiation; C2C12 Cell; Bone Morphogenic Protein; BMP2 Signaling;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [41] TWEAK/Fn14 interaction regulates RANTES production, BMP-2-induced differentiation, and RANKL expression in mouse osteoblastic MC3T3-E1 cells
    Takashi Ando
    Jiro Ichikawa
    Masanori Wako
    Kyosuke Hatsushika
    Yoshiyuki Watanabe
    Michitomo Sakuma
    Kachio Tasaka
    Hideoki Ogawa
    Yoshiki Hamada
    Hideo Yagita
    Atsuhito Nakao
    Arthritis Research & Therapy, 8
  • [42] Downregulation of Wnt signaling by increased expression of Dickkopf-1 and-2 is a prerequisite for late-stage osteoblast differentiation of KS483 cells
    van der Horst, G
    van der Wert, SM
    Farih-Sips, H
    van Bezooijen, RL
    Löwik, CWGM
    Karperien, M
    JOURNAL OF BONE AND MINERAL RESEARCH, 2005, 20 (10) : 1867 - 1877
  • [43] Olig2-Induced Neural Stem Cell Differentiation Involves Downregulation of Wnt Signaling and Induction of Dickkopf-1 Expression
    Ahn, Sung-Min
    Byun, Kyunghee
    Kim, Deokhoon
    Lee, Kiyoung
    Yoo, Jong Shin
    Kim, Seung U.
    Jho, Eek-hoon
    Simpson, Richard J.
    Lee, Bonghee
    PLOS ONE, 2008, 3 (12):
  • [44] WNT4 acts downstream of BMP2 to mediate the regulation of ATRA signaling on RUNX1 expression: Implications for terminal differentiation of antler chondrocytes
    Zhang, Hong-Liang
    Yang, Zhan-Qing
    Duan, Cui-Cui
    Geng, Shuang
    Wang, Kai
    Yu, Hai-Fan
    Yue, Zhan-Peng
    Guo, Bin
    JOURNAL OF CELLULAR PHYSIOLOGY, 2018, 233 (02) : 1129 - 1145
  • [45] Phosphatidylinositol (PI) 3 kinase/Akt signaling represents a potential mechanism for BMP-2-induced expression of colony stimulating factor-1 (CSF-1) which mediates osteoclast differentiation.
    Mandal, C. C.
    Singha, P. K.
    Pandeswara, S. L.
    Ghosh-Choudhury, G.
    Ghosh-Choudhury, N.
    JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 : S95 - S95
  • [46] Bisphosphonate- and statin-induced enhancement of OPG expression and inhibition of CD9, M-CSF, and RANKL expressions via inhibition of the Ras/MEK/ERK pathway and activation of p38MAPK in mouse bone marrow stromal cell line ST2
    Tsubaki, Masanobu
    Satou, Takao
    Itoh, Tatsuki
    Imano, Motohiro
    Yanae, Masashi
    Kato, Chisato
    Takagoshi, Risa
    Komai, Makiko
    Nishida, Shozo
    MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2012, 361 (1-2) : 219 - 231
  • [47] Sclerostin inhibits osteoblast differentiation without affecting BMP2/SMAD1/5 or Wnt3a/beta-catenin signaling but through activation of platelet-derived growth factor receptor signaling in vitro
    Thouverey, Cyril
    Caverzasio, Joseph
    BONEKEY REPORTS, 2015, 4
  • [48] Phosphatidylinositol 3 kinase (PI3K)-dependent Erk1/2 activation represents a novel mechanism of statin-induced BMP-2 expression and osteoblast differentiation.
    Ghosh-Choudhury, N
    JOURNAL OF BONE AND MINERAL RESEARCH, 2005, 20 (09) : S79 - S79
  • [49] Chitosan Regulates CAV1 to Facilitate M2 Macrophage Differentiation through Activation of Canonical Wnt Signaling Pathway in Diabetic Skin Trauma Model Rats
    Gao, Jie
    Xia, Lianheng
    Jia, Zhen
    Zhang, Jiayuan
    Song, Meiyu
    Ding, Wukun
    Li, Linggen
    Liang, Xuewei
    JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS, 2023, 37 (08): : 4335 - 4343
  • [50] Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways
    Bai, Yiling
    Wu, Zhaojia
    Leary, Scot C.
    Fang, Chen
    Yu, Michelle
    Genth, Harald
    Xie, Yufeng
    Shi, Jinhui
    Xiang, Jim
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 26 (04)