A convenient method for 14C-labeling of 2-methylthio-1-[4-N-α-ethoxycarbonylbenzyl)-amino-benzyl]-5-hydroxymethyl-2-[14C]-1H-imidazole and 1-[4-N-α-ethoxy-carbonylbenzyl)-aminobenzyl]-5-hydroxymethyl-2-[14C]-1H-imidazole as potential antihypertensives

被引：0
|
作者：
Nader Saemian
Gholamhossein Shirvani
Sayed Sajad Oliyaee
Mohsen Javaheri
机构：
[1] Nuclear Science & Technology Research Institute,Nuclear Science Research School
[2] Azad University,Department of Chemistry, Engineering Faculty
来源：
Journal of Radioanalytical and Nuclear Chemistry | 2012年 / 292卷
关键词：
Nonpeptide angiotensin II; Imidazole; Carbon-14; One pot procedure;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The key synthetic intermediate, (2-mercapto-1-(4-nitrobenzyl)-1H-imidazol-5-yl)methanol-[2-14C], has been synthesized by using one pot procedure from potassium[14C]-thiocyanate. It was converted to two nonpeptide angiotensin II receptor antagonists, 2-methylthio-1-[4-N-α-ethoxycarbonyl benzyl)-aminobenzyl]-5-hydroxymethyl-1H-imidazole-[2-14C] and 1-[4-N-α-ethoxy-carbonylbenzyl)-aminobenzyl]-5-hydroxymethyl-1H-imidazole-[2-14C] via a 3-step sequence synthetic pathway.
引用
收藏
页码：237 / 241
页数：4
相关论文
共 50 条
  • [21] Crystal structure of 1H-indole-5-carboxylic acid-4,4′-bipyridine (2/1), C14H11N2O2
    Deng Linxin
    Kuang Xinya
    Yang Huarong
    Li Song
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2019, 234 (02): : 191 - 192
  • [22] Crystal structure of dichloro-(1,4-cyclohexanedicarboxylato)bis[1,2-bis(imidazole-1-ylmethyl)benzene]dicadmium(II) hydrate, Cd2Cl2(C14H14N4)2(C8H10O4) • H2O
    Xia, Dao-Cheng
    Li, Wan-Cheng
    Han, Shuang
    Han, Qiu-Ping
    Zhang, Wen-Chan
    Ma, Hui-Xuan
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2010, 225 (01): : 69 - 70
  • [23] Crystal structure of bis(1,3-diaminoimidazolium) 5,5′-azotetrazolate, (C3H7N4)2 (C2N10), C8H14N18
    Laus, Gerhard
    Wurst, Klaus
    Schottenberger, Herwig
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2012, 227 (03): : 293 - 294
  • [24] Crystal structure of catena-(μ2-5-hydroxybenzene-1,3-dicarboxylato)-(μ2-1,1′-(1,4-butyl)bis(imidazole))cobalt(II), Co(C8H4O5)(C10H14N4)
    Fu, Rui-Li
    Ma, Jian-Fang
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2012, 227 (02): : 281 - 282
  • [25] Crystal structure of aqua[1,4-bis((1H-imidazol-1-yl)methyl)benzene]-(5-hydroxyisophthalato)cadmium(II), Cd(H2O)(C14H14N4)(C8H4O5)
    Xia, Dao-Cheng
    Yao, Ji-Huan
    Zhang, Wen-Chan
    Huang, Ren-Qiang
    Yang, Xu-Qing
    Jing, Jing-Jing
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2011, 226 (01): : 17 - 18
  • [26] Crystal structure of [(3-carboxyl-1-(4-carboxylphenylmethylene)-2-oxidopyrinium-κ2O1,O2)chloride(pyrazino[2,3-f]-[1,10]phenanthroline-κ2N1,N2)copper], [Cu(C14H10NO5)Cl(C14H8N4)], C28H18ClCuN5O5
    Li, Sha-Sha
    Wang, Yuan-Rui
    Sun, Lin-Ping
    Li, Ya-Feng
    Qiao, Qian
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 2014, 229 (02): : 131 - 132
  • [27] 13C- and 14C-labelling of N-[1-(4-chlorophenyl-1H-pyrrol-2-yl-methyleneamino] guanidinium acetate
    Almeida, M
    Johannesson, P
    Boman, A
    Lundstedt, T
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 2005, 48 (08): : 621 - 627
  • [28] Crystal structure of bis[R-(+)-1-(1-naphthyl)ethylammonium]squarate, [C12H14N]2C4O4
    Kolev, T
    Glavcheva, Z
    Schürmann, M
    Preut, H
    Bleckmann, P
    Radomirska, V
    ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES, 1999, 214 (02): : 187 - 188
  • [29] 1-(2[4-METHYLIMIDAZOL-5-YL)METHYLTHIO]ETHYLAMINO)1-METHYLAMINO-2-NITROETHENE, C10H17N5O2S
    GLOVER, PE
    PROUT, K
    CRYSTAL STRUCTURE COMMUNICATIONS, 1981, 10 (04): : 1295 - 1299
  • [30] The structure of 1-[2-[[(4-chlorophenyl)-methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole (sulconazole) nitrate, C18H16Cl3N3O3S
    Shin, HS
    Song, H
    Cho, SI
    Park, KI
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 1997, 18 (01) : 14 - 18
12345