A convenient method for 14C-labeling of 2-methylthio-1-[4-N-α-ethoxycarbonylbenzyl)-amino-benzyl]-5-hydroxymethyl-2-[14C]-1H-imidazole and 1-[4-N-α-ethoxy-carbonylbenzyl)-aminobenzyl]-5-hydroxymethyl-2-[14C]-1H-imidazole as potential antihypertensives

被引：0

作者：

Nader Saemian

Gholamhossein Shirvani

Sayed Sajad Oliyaee

Mohsen Javaheri

机构：

[1] Nuclear Science & Technology Research Institute,Nuclear Science Research School

[2] Azad University,Department of Chemistry, Engineering Faculty

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2012年 / 292卷

关键词：

Nonpeptide angiotensin II; Imidazole; Carbon-14; One pot procedure;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The key synthetic intermediate, (2-mercapto-1-(4-nitrobenzyl)-1H-imidazol-5-yl)methanol-[2-14C], has been synthesized by using one pot procedure from potassium[14C]-thiocyanate. It was converted to two nonpeptide angiotensin II receptor antagonists, 2-methylthio-1-[4-N-α-ethoxycarbonyl benzyl)-aminobenzyl]-5-hydroxymethyl-1H-imidazole-[2-14C] and 1-[4-N-α-ethoxy-carbonylbenzyl)-aminobenzyl]-5-hydroxymethyl-1H-imidazole-[2-14C] via a 3-step sequence synthetic pathway.

引用

页码：237 / 241

页数：4

共 50 条

[1] A convenient method for 14C-labeling of 2-methylthio-1-[4-N-α-ethoxycarbonylbenzyl)-amino-benzyl]-5-hydroxymethyl-2-[14C]-1H-imidazole and 1-[4-N-α-ethoxy-carbonylbenzyl)-aminobenzyl]-5-hydroxymethyl-2-[14C]-1H-imidazole as potential antihypertensives
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Shirvani, Gholamhossein
Oliyaee, Sayed Sajad
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