Insertion of tandem direct repeats consisting of avian leukosis virus LTR sequences into the inverted repeat region of Marek's disease virus type 1 DNA

被引：18
|
作者：
Sakaguchi M. [1 ]
Sonoda K. [1 ]
Matsuo K. [1 ]
Zhu G.-S. [2 ]
Hirai K. [2 ]
机构：
[1] Chemo-Sero Therapeut. Res. Institute, Kikuchi Research Center
[2] Department of Cell Regulation, Medical Research Institute, Tokyo Medical and Dental University, Bunkyo-ku
来源：
Virus Genes | 1997年 / 14卷 / 2期
关键词：
ALV; Insertion; LTR; Marek's disease; MDV1; Repeated sequence;
D O I：
10.1023/A:1007925519587
中图分类号：
学科分类号：
摘要：
The BC-1 strain DNA of Marek's disease virus type 1 (MDV1) at high-passage in culture was found to contain tandem direct repeats of the complete long terminal repeat (LTR) sequence of avian leukosis virus RAVO strain as the repeat unit within the short inverted repeats of the MDV1 DNA. Since the attenuated BC-1 strain grows well in cultured cells, the insertion site for retroviral DNA sequence within the short inverted repeat of MDV1 DNA is not essential for viral growth in culture.
引用
收藏
页码：157 / 162
页数：5
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