Two new glutarimide antibiotics from Streptomyces sp. HS-NF-780

被引：0
|
作者：
Xue-Li Zhao
Han Wang
Zheng-Lian Xue
Jian-Song Li
Huan Qi
Hui Zhang
Tian Zhao
Ji-Dong Wang
Wen-Sheng Xiang
机构：
[1] Northeast Agricultural University,Life Science and Biotechnology Research Center, School of Life Science
[2] Anhui Polytechnic University,College of Biochemical Engineering
[3] Zhejiang Hisun Pharmaceutical Co.,Zhejiang Key Laboratory of Antifungal Drugs
[4] Ltd,undefined
来源：
The Journal of Antibiotics | 2019年 / 72卷
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摘要：
Two new glutarimide antibiotics, 9-methylstreptimidone 2-α-d-glucopyranoside (1), and hydroxyiso-9-methylstreptimidone (2), along with a known compound, 9-methylstreptimidone (3), have been isolated from the broth of Streptomyces sp. HS-NF-780. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. By modified Mosher’s method and acid hydrolysis, the absolute configurations of compounds 1 and 2 were established. Compounds 1 and 2 exhibited moderate cytotoxic activity.
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页码：241 / 245
页数：4
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