metaBEETL: high-throughput analysis of heterogeneous microbial populations from shotgun DNA sequences

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作者
Christina Ander
Ole B Schulz-Trieglaff
Jens Stoye
Anthony J Cox
机构
[1] Bielefeld University,Genome Informatics, Faculty of Technology and CeBiTec
[2] Chesterford Research Park,Computational Biology Group, Illumina Cambridge Ltd.
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Suffix; Taxonomic Classification; Copy Number Change; Human Microbiome Project; Suffix Array;
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摘要
Environmental shotgun sequencing (ESS) has potential to give greater insight into microbial communities than targeted sequencing of 16S regions, but requires much higher sequence coverage. The advent of next-generation sequencing has made it feasible for the Human Microbiome Project and other initiatives to generate ESS data on a large scale, but computationally efficient methods for analysing such data sets are needed.
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