Circulating miRNAs as predictors for morbidity and mortality in coronary artery disease

被引：0

作者：

Barbara Mayr

Josef Niebauer

Hannelore Breitenbach-Koller

机构：

[1] Paracelsus Medical University,University Institute of Sports Medicine, Prevention and Rehabilitation and Research Institute of Molecular Sports Medicine and Rehabilitation

[2] Salzburg,Department of Bioscience

[3] University of Salzburg,undefined

[4] Salzburg,undefined

来源：

Molecular Biology Reports | 2019年 / 46卷

关键词：

Biomarker; microRNA; CAD;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Micro ribonucleic acids (miRNAs) are small non-coding RNA molecules that control gene expression by translational inhibition. They have been identified to play a role in a multitude of physiological and pathophysiological cellular processes amongst others in the heart. Due to their ability to be released into the blood as well as their stability in body fluids, they appear suitable as biomarkers. This review discusses the role of selected miRNA that currently emerge as biomarkers for coronary artery disease, their potential to discriminate between different diseases, as well as how they might be used as predictive tools for cardiac events or disease outcome. Furthermore, we propose procedural steps of miRNA analysis, to allow better comparison between studies in the future.

引用

页码：5661 / 5665

页数：4

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