Prodigiosin biosynthesis gene cluster in the roseophilin producer Streptomyces griseoviridis

被引：0
|
作者：
Takashi Kawasaki
Fumi Sakurai
Shun-ya Nagatsuka
Yoichi Hayakawa
机构：
[1] Faculty of Pharmaceutical Sciences,Department of Medicinal and Life Science
[2] Tokyo University of Science,undefined
[3] Yamazaki,undefined
来源：
The Journal of Antibiotics | 2009年 / 62卷
关键词：
biosynthesis gene; prodigiosin; roseophilin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Streptomyces griseoviridis 2464-S5 produces prodigiosin R1, a tripyrrole antibiotic, and roseophilin, a structurally related compound containing two pyrrole and one furan rings. A gene cluster for the biosynthesis of a prodigiosin was identified in S. griseoviridis. The cluster consisted of 24 open reading frames, including 21 genes (rphD–rphZ) homologous to prodigiosin biosynthesis genes in the red cluster in Streptomyces coelicolor A3(2). The expression of rphN in S. coelicolor lacking redN restored the production of prodigiosin.
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页码：271 / 276
页数：5
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