Exploring the potential anti-Alzheimer disease mechanisms of Alpiniae Oxyphyliae Fructus by network pharmacology study and molecular docking

被引:0
|
作者
Rong-Rong Zhen
Yan-Jie Qu
Li-Min Zhang
Chao Gu
Min-Rui Ding
Lei Chen
Xiao Peng
Bing Hu
Hong-Mei An
机构
[1] Shanghai University of Traditional Chinese Medicine,Department of Neurology, Longhua Hospital
[2] Shanghai University of Traditional Chinese Medicine,Institute of Traditional Chinese Medicine in Oncology, Department of Oncology, Longhua Hospital
[3] Shanghai University of Traditional Chinese Medicine,Department of Science & Technology, Longhua Hospital
来源
Metabolic Brain Disease | 2023年 / 38卷
关键词
Alzheimer disease; Chinese herb; Fructus; Network pharmacology;
D O I
暂无
中图分类号
学科分类号
摘要
Alpiniae Oxyphyliae Fructus (AOF) (yizhi) is a frequently medicated Chinese herb for Alzheimer disease (AD) treatment. The present study investigated the components and potential mechanisms of AOF through network pharmacology analysis and molecular docking. The results showed that AOF contains at least 20 active ingredients and involves 184 target genes. A total of 301 AD-related genes were obtained from the DisGeNET, GeneCards, GEO, OMIM, and Alzheimer Disease: Genes databases. A total of 41 key targets were identified from the topology analysis of the AOF-AD target network. These key targets are involved in 105 signal pathways, such as the PI3K-Akt, HIF-1, and MAPK pathways, and can regulate gene transcription, cell death, cell proliferation, drug response, and protein phosphorylation. AOF’s active ingredients, Chrysin, Isocyperol, Izalpinin, Linolenic acid, CHEMBL489541, Oxyphyllenone A, Oxyphyllenone B, and Oxyphyllol C, show high affinity to targets, including PPARG, ESR1, and AKT1. These findings provide a new basis for AOF application and anti-AD study.
引用
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页码:933 / 944
页数:11
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