Improved Synthesis of 2-(1-Adamantyl)-4-bromophenol and 2-(1-Adamantyl)-4-bromoanisole, Intermediates in Adapalene Synthesis

被引：0
|
作者：
V. A. Sokolenko*
N. M. Svirskaya
I. V. Peterson
A. I. Rubailo
机构：
[1] Siberian Branch of the Russian Academy of Sciences,Institute of Chemistry and Chemical Technology
[2] Siberian Federal University,undefined
来源：
Pharmaceutical Chemistry Journal | 2013年 / 47卷
关键词：
adapalene; 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid; 2-(1-adamantyl)-4-bromophenol; 2-(1-adamantyl)-4-bromoanisole; 1-adamantanol; 1-bromoadamantane; synthesis; alkylation;
D O I：
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中图分类号：
学科分类号：
摘要：
A new simple and environmentally friendly synthetic method for 2-(1-adamantyl)-4-bromophenol that did not use catalysts and solvents was developed. A new simplified preparation method for 2-(1-adamantyl)-4-bromoanisole in one step instead of two was proposed. Both compounds are intermediates in the first and second synthetic steps to 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid (adapalene).
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页码：217 / 218
页数：1
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