Therapeutic Applications for Adipose-Derived Stem Cells in Wound Healing and Tissue Engineering

被引：13
|
作者：
McCarthy M.E. [1 ]
Brown T.A. [1 ]
Bukowska J. [1 ,2 ]
Bunnell B.A. [1 ,3 ,4 ]
Frazier T. [5 ,8 ]
Wu X. [8 ]
Gimble J.M. [1 ,5 ,6 ,7 ,8 ]
机构：
[1] Center for Stem Cell Research and Regenerative Medicine, Tulane University, New Orleans, LA
[2] Polish Academy of Science, Olsztyn
[3] Department of Pharmacology, Tulane University, New Orleans, LA
[4] Tulane National Primate Research Center, Tulane University, New Orleans, LA
[5] Department of Structural and Cell Biology, Tulane University, New Orleans, LA
[6] Department of Medicine, Tulane University, New Orleans, LA
[7] Department of Surgery, Tulane University, New Orleans, LA
[8] LaCell LLC and Obatala Sciences Inc, New Orleans, LA
来源：
Current Stem Cell Reports | 2018年 / 4卷 / 2期
关键词：
Adipose-derived stem cells; Cytokine; Pressure ulcers; Scaffold; Skin wound healing; Stromal vascular fraction;
D O I：
10.1007/s40778-018-0125-9
中图分类号：
学科分类号：
摘要：
Purpose of Review: The use of adipose-derived stem cells (ASCs) has garnered recent interest for their accessibility and potential utility in wound healing applications. The purpose of this review is to provide an overview of developments within the last 5 years regarding therapeutic use of ASCs in wound healing applications. Recent Findings: Recent studies have demonstrated that ASCs do not exert the majority of their effects through differentiation, as previously believed. Rather, when they improve healing, it is via secreted factors that promote vascularization and control inflammation. New therapeutic approaches reflect this shift in belief. Summary: ASC-based therapies can improve outcomes in the treatment of a variety of wound types. Questions about how to best implement ASCs in the clinical setting remain, and their answers will profoundly influence the utility and availability of ASC-based therapies. © 2018, Springer International Publishing AG, part of Springer Nature.
引用
收藏
页码：127 / 137
页数：10
相关论文
共 50 条
  • [31] A composite of human adipose-derived extracellular matrix and adipose-derived stem cells for cartilage tissue engineering
    Choi, J. S.
    Kim, J. D.
    Kim, E. J.
    Cho, Y. W.
    JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2012, 6 : 176 - 177
  • [32] MANUFACTURE AND CHARACTERISATION OF EX VIVO EXPANDED ADIPOSE-DERIVED STEM CELLS FOR CUTANEOUS WOUND HEALING APPLICATIONS
    Luck, J.
    Weil, B.
    Mosahebi, A.
    Lowdell, M.
    CYTOTHERAPY, 2021, 23 (05) : S177 - S177
  • [33] ADHESIVE INJECTABLE HYDROGEL ENCAPSULATED WITH ADIPOSE-DERIVED STEM CELLS FOR WOUND HEALING
    Lee, X. Y.
    Wang, W.
    IRISH JOURNAL OF MEDICAL SCIENCE, 2015, 184 : 551 - 552
  • [34] Surgical Sutures Filled with Adipose-Derived Stem Cells Promote Wound Healing
    Reckhenrich, Ann Katharin
    Kirsch, Bianca Manuela
    Wahl, Elizabeth Ann
    Schenck, Thilo Ludwig
    Rezaeian, Farid
    Harder, Yves
    Foehr, Peter
    Machens, Hans-Guenther
    Tomas Egana, Jose
    PLOS ONE, 2014, 9 (03):
  • [35] The biologic effects of adipose-derived stem cells on wound healing in a mouse model
    Lee, June
    Lee, Chang Woo
    Cho, Kwang Hyun
    Kim, Mi Sun
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 2013, 68 (04) : AB10 - AB10
  • [36] Adipose-derived stem cells in wound healing: comparison with fibroblasts and keratinocytes interaction
    Benassi, L.
    Tarentini, E.
    Rossi, E.
    Paganelli, A.
    Vaschieri, C.
    Pellegrini, M.
    Pellacani, G.
    Magnoni, C.
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2019, 139 (09) : S326 - S326
  • [37] Genetic modification of human adipose-derived stem cells for promoting wound healing
    Song, Seung-Hyun
    Lee, Mi-Ok
    Lee, Ji-Seon
    Jeong, Ho-Chang
    Kim, Hyung-Gi
    Kim, Won-Serk
    Hur, Mina
    Cha, Hyuk-Jin
    JOURNAL OF DERMATOLOGICAL SCIENCE, 2012, 66 (02) : 98 - 107
  • [38] The Effect of Adipose-Derived Stem Cells on Wound Healing: Comparison of Methods of Application
    Kim, Hyeonwoo
    Hyun, Mi Ri
    Kim, Sang Wha
    STEM CELLS INTERNATIONAL, 2019, 2019
  • [39] Exosomes from adipose-derived stem cells and application to skin wound healing
    An, Yang
    Lin, Shuyan
    Tan, Xiaojie
    Zhu, Shiou
    Nie, Fangfei
    Zhen, Yonghuan
    Gu, Luosha
    Zhang, Chunlei
    Wang, Baicheng
    Wei, Wei
    Li, Dong
    Wu, Junhao
    CELL PROLIFERATION, 2021, 54 (03)
  • [40] Healing of grafted adipose tissue: Current clinical applications of adipose-derived stem cells for breast and face reconstruction
    Philips, Brian J.
    Marra, Kacey G.
    Rubin, J. Peter
    WOUND REPAIR AND REGENERATION, 2014, 22 : 11 - 13
12345