Levodopa improves handwriting and instrumental tasks in previously treated patients with Parkinson’s disease

被引:0
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作者
Thomas Müller
Ali Harati
机构
[1] St. Joseph Hospital Berlin-Weissensee,Department of Neurology
[2] Pan Klinik Am Neumarkt,Private Practice for Neurosurgery, MVZ PAN Institute GmbH within the Department of Neurosurgery
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关键词
Levodopa; Parkinson’s disease; Motor behavior; Handwriting;
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摘要
Motor symptoms in patients with Parkinson’s disease may be determined with instrumental tests and rating procedures. Their outcomes reflect the functioning and the impairment of the individual patient when patients are tested off and on dopamine substituting drugs. Objectives were to investigate whether the execution speed of a handwriting task, instrumentally assessed fine motor behavior, and rating scores improve after soluble levodopa application. 38 right-handed patients were taken off their regular drug therapy for at least 12 h before scoring, handwriting, and performance of instrumental devices before and 1 h after 100 mg levodopa intake. The outcomes of all performed procedures improved. The easy-to-perform handwriting task and the instrumental tests demand for fast and precise execution of movement sequences with considerable cognitive load in the domains' attention and concentration. These investigations may serve as additional tools for the testing of the dopaminergic response.
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页码:1369 / 1376
页数:7
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