The Tissue-Specific Methylation of Human-Specific Endogenous Retroviral LTRs

被引：0
|
作者：
K. V. Khodosevich
Yu. B. Lebedev
E. D. Sverdlov
机构：
[1] Russian Academy of Sciences,Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry
来源：
Russian Journal of Bioorganic Chemistry | 2004年 / 30卷
关键词：
endogenous retroviruses; gene expression; human genome evolution; methylation;
D O I：
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中图分类号：
学科分类号：
摘要：
A possible involvement of retroelements in the epigenetic regulation of human gene expression was considered by the example of methylation of long terminal repeats (LTRs) of the human endogenous retrovirus family K (HERV-K). The methylation status of six HERV-K LTRs was determined in various gene-enriched regions of the human genome. The methylation of four LTRs was shown to be tissue-specific. Our results correlated with published data on the tissue-specific changes in the expression level of human genes adjacent to the LTRs under study.
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页码：441 / 445
页数：4
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