Synthesis of 1,3-Disubstituted Ureas Containing Cycloheptyl or Bicyclo[2.2.1]heptyl Fragments, as Soluble Epoxide Hydrolase Inhibitors

被引：0

作者：

V. V. Burmistrov

E. V. Rasskazova

V. S. D’yachenko

A. A. Vernigora

G. M. Butov

机构：

[1] Volgograd State Technical University,Volzhsky Polytechnic Institute (Branch)

[2] Volgograd State Technical University,undefined

来源：

Russian Journal of Organic Chemistry | 2019年 / 55卷

关键词：

camphor; norbornyl; 1,3-disubstituted ureas; soluble epoxide hydrolase; sEH;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

To assess the effect of the lipophilicity of different parts of urea molecules on their activity as soluble epoxide hydrolase inhibitors, a series of 1,3-disubstituted ureas containing cycloheptane and bicyclo-[2.2.1]heptane fragments were prepared by the reaction of isocyanates with corresponding amines in 78–94% yields.

引用

页码：1136 / 1144

页数：8

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