Association between ABO blood group/genotype and COVID-19 in a Japanese population

被引：0

作者：

Tatsuya Kusumoto

Shotaro Chubachi

Ho Namkoong

Hiromu Tanaka

Ho Lee

Shuhei Azekawa

Shiro Otake

Kensuke Nakagawara

Takahiro Fukushima

Atsuho Morita

Mayuko Watase

Kaori Sakurai

Takanori Asakura

Katsunori Masaki

Hirofumi Kamata

Makoto Ishii

Naoki Hasegawa

Norihiro Harada

Tetsuya Ueda

Soichiro Ueda

Takashi Ishiguro

Ken Arimura

Fukuki Saito

Takashi Yoshiyama

Yasushi Nakano

Yoshikazu Mutoh

Yusuke Suzuki

Ryuya Edahiro

Hirohito Sano

Yasunori Sato

Yukinori Okada

Ryuji Koike

Yuko Kitagawa

Katsushi Tokunaga

Akinori Kimura

Seiya Imoto

Satoru Miyano

Seishi Ogawa

Takanori Kanai

Koichi Fukunaga

机构：

[1] Keio University School of Medicine,Division of Pulmonary Medicine, Department of Medicine

[2] Keio University School of Medicine,Department of Infectious Diseases

[3] National Hospital Organization Tokyo Medical Center,Department of Respiratory Medicine

[4] Kitasato University Kitasato Institute Hospital,Department of Respiratory Medicine

[5] Nagoya University Graduate School of Medicine,Department of Respiratory Medicine

[6] Juntendo University Faculty of Medicine and Graduate School of Medicine,Department of Respiratory Medicine

[7] Osaka Saiseikai Nakatsu Hospital,Department of Respiratory Medicine

[8] JCHO (Japan Community Health Care Organization) Saitama Medical Center,Department of Internal Medicine

[9] Saitama Cardiovascular and Respiratory Center,Department of Respiratory Medicine

[10] Tokyo Women’s Medical University,Department of Respiratory Medicine

[11] Kansai Medical University General Medical Center,Department of Emergency and Critical Care Medicine

[12] Fukujuji Hospital,Respiratory Disease Center

[13] Japan Anti-Tuberculosis Association,Department of Internal Medicine

[14] Kawasaki Municipal Ida Hospital,Department of Infectious Diseases

[15] Tosei General Hospital,Department of Respiratory Medicine and Clinical Immunology

[16] Osaka University Graduate School of Medicine,Department of Respiratory Medicine

[17] Tohoku University Graduate School of Medicine,Department of Preventive Medicine and Public Health

[18] Keio University School of Medicine,Department of Statistical Genetics

[19] Osaka University Graduate School of Medicine,Integrated Frontier Research for Medical Science Division

[20] Institute for Open and Transdisciplinary Research Initiatives,The Center for Infectious Disease Education and Research (CiDER)

[21] Osaka University,Laboratory of Statistical Immunology, Immunology Frontier Research Center (WPI

[22] Osaka University,IFReC)

[23] the University of Tokyo,Department of Genome Informatics, Graduate School of Medicine

[24] Laboratory for Systems Genetics,Medical Innovation Promotion Center

[25] RIKEN Center for Integrative Medical Sciences,Department of Surgery

[26] Tokyo Medical and Dental University,Genome Medical Science Project (Toyama)

[27] Keio University School of Medicine,Institute of Research

[28] National Center for Global Health and Medicine,Division of Health Medical Intelligence

[29] Tokyo Medical and Dental University,M&D Data Science Center

[30] Human Genome Center,Department of Pathology and Tumor Biology

[31] the Institute of Medical Science,Institute for the Advanced Study of Human Biology (WPI

[32] the University of Tokyo,ASHBi)

[33] Tokyo Medical and Dental University,Department of Medicine, Center for Hematology and Regenerative Medicine

[34] Kyoto University,Division of Gastroenterology and Hepatology, Department of Medicine

[35] Kyoto University,undefined

[36] Karolinska Institute,undefined

[37] Keio University School of Medicine,undefined

来源：

Annals of Hematology | 2023年 / 102卷

关键词：

COVID-19; ABO blood group; ABO genotype; Japanese population;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

An association between coronavirus disease 2019 (COVID-19) and the ABO blood group has been reported. However, such an association has not been studied in the Japanese population on a large scale. Little is known about the association between COVID-19 and ABO genotype. This study investigated the association between COVID-19 and ABO blood group/genotype in a large Japanese population. All Japanese patients diagnosed with COVID-19 were recruited through the Japan COVID-19 Task Force between February 2020 and October 2021. We conducted a retrospective cohort study involving 1790 Japanese COVID-19 patients whose DNA was used for a genome-wide association study. We compared the ABO blood group/genotype in a healthy population (n = 611, control) and COVID-19 patients and then analyzed their associations and clinical outcomes. Blood group A was significantly more prevalent (41.6% vs. 36.8%; P = 0.038), and group O was significantly less prevalent (26.2% vs. 30.8%; P = 0.028) in the COVID-19 group than in the control group. Moreover, genotype OO was significantly less common in the COVID-19 group. Furthermore, blood group AB was identified as an independent risk factor for most severe diseases compared with blood group O [aOR (95% CI) = 1.84 (1.00–3.37)]. In ABO genotype analysis, only genotype AB was an independent risk factor for most severe diseases compared with genotype OO. Blood group O is protective, whereas group A is associated with the risk of infection. Moreover, blood group AB is associated with the risk of the “most” severe disease.

引用

页码：3239 / 3249

页数：10

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