Pharmacokinetic Factors in the Adverse Cardiovascular Effects of Antipsychotic Drugs

被引：0
|
作者：
Candace S. Brown
Richard G. Farmer
Judith E. Soberman
Samantha F. Eichner
机构：
[1] University of Tennessee Health Sciences Center,Departments of Pharmacy and Obstetrics/Gynecology
[2] University of Tennessee Health Sciences Center,Department of Psychiatry
[3] University of Tennessee Health Sciences Center,Department of Medicine (Cardiology)
[4] University of Tennessee Health Sciences Center,Department of Pharmacy (Drug Information Center)
来源：
Clinical Pharmacokinetics | 2004年 / 43卷
关键词：
Haloperidol; Clozapine; Risperidone; Olanzapine; Clarithromycin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Antipsychotics may cause serious adverse cardiovascular effects, including prolonged QT interval and sudden death. This review considers antipsychotic-induced cardiovascular events from three perspectives: high-risk drugs, high-risk individuals and high-risk drug interactions. Pharmacokinetic drug interactions involving the cytochrome P450 (CYP) enzymatic pathway and pharmacodynamic interactions leading to direct cardiotoxic effects are discussed. Original reports on antipsychotic-induced drug interactions are reviewed, with consideration of management guidelines.
引用
收藏
页码：33 / 56
页数：23
相关论文
共 50 条
  • [41] Antipsychotic drugs & their side effects
    Jacob, Rajesh
    INDIAN JOURNAL OF MEDICAL RESEARCH, 2009, 129 (02) : 208 - 209
  • [42] Extrapyramidal effects of antipsychotic drugs
    Kulisevsky, J
    Otermin, P
    NEUROLOGIA, 2003, 18 (05): : 262 - 268
  • [43] Charge is an important determinant of hemodynamic and adverse cardiovascular effects of cationic drugs
    Pugsley, Michael K.
    Authiera, Simon
    Curtis, Michael J.
    PHARMACOLOGICAL RESEARCH, 2015, 102 : 46 - 52
  • [44] Adverse Cardiovascular Effects of Antirheumatic Drugs: Implications for Clinical Practice and Research
    Gasparyan, Armen Yuri
    Ayvazyan, Lilit
    Cocco, Giuseppe
    Kitas, George D.
    CURRENT PHARMACEUTICAL DESIGN, 2012, 18 (11) : 1543 - 1555
  • [45] EFFECTS OF ANTIHYPERTENSIVE DRUGS ON CARDIOVASCULAR RISK-FACTORS
    HOWES, LG
    LOUIS, WJ
    CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1988, 15 (03) : 199 - 202
  • [46] ADVERSE-EFFECTS OF ANTIPSYCHOTIC AGENTS
    SIMPSON, GM
    PI, EH
    SRAMEK, JJ
    DRUGS, 1981, 21 (02) : 138 - 151
  • [47] Pharmacogenomics of antipsychotic adverse effects: Focus on antipsychotic induced parkinsonism
    Lerer, B.
    Greenbaum, L.
    Strous, R.
    Rigbi, A.
    Lancet, D.
    Kanyas, K.
    Ben-Asher, E.
    Smith, R.
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2008, 11 : 33 - 33
  • [48] Guidelines for prevention and treatment of adverse effects of antipsychotic drugs on glucose–insulin homeostasis and lipid metabolism
    K. I. Melkersson
    M.-L. Dahl
    A.-L. Hulting
    Psychopharmacology, 2004, 175 : 1 - 6
  • [49] Review: In multiepisode schizophrenia, most antipsychotic drugs improve symptoms; adverse effects vary by drug
    Budenholzer, Brian
    ANNALS OF INTERNAL MEDICINE, 2019, 171 (10) : JC57 - JC57
  • [50] Pharmacokinetic and pharmacodynamic responses to cardiovascular drugs in Asians
    Acta Pharmacologica Sinica, 1998, (S1) : 15 - 16
12345