Pharmacokinetic Factors in the Adverse Cardiovascular Effects of Antipsychotic Drugs

被引：0
|
作者：
Candace S. Brown
Richard G. Farmer
Judith E. Soberman
Samantha F. Eichner
机构：
[1] University of Tennessee Health Sciences Center,Departments of Pharmacy and Obstetrics/Gynecology
[2] University of Tennessee Health Sciences Center,Department of Psychiatry
[3] University of Tennessee Health Sciences Center,Department of Medicine (Cardiology)
[4] University of Tennessee Health Sciences Center,Department of Pharmacy (Drug Information Center)
来源：
Clinical Pharmacokinetics | 2004年 / 43卷
关键词：
Haloperidol; Clozapine; Risperidone; Olanzapine; Clarithromycin;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Antipsychotics may cause serious adverse cardiovascular effects, including prolonged QT interval and sudden death. This review considers antipsychotic-induced cardiovascular events from three perspectives: high-risk drugs, high-risk individuals and high-risk drug interactions. Pharmacokinetic drug interactions involving the cytochrome P450 (CYP) enzymatic pathway and pharmacodynamic interactions leading to direct cardiotoxic effects are discussed. Original reports on antipsychotic-induced drug interactions are reviewed, with consideration of management guidelines.
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收藏
页码：33 / 56
页数：23
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