The Effectiveness of Cyclic Hydroxamic Acid CHA-5 against Drug-Resistant P388 Leukemia Strains

被引：0

作者：

S. A. Goncharova

I. V. Vystorop

T. A. Raevskaya

N. P. Konovalova

机构：

[1] Russian Academy of Sciences,Institute of Problems of Chemical Physics

来源：

Bulletin of Experimental Biology and Medicine | 2017年 / 163卷

关键词：

tumor drug resistance; cyclic hydroxamic acids; murine P388 lymphocytic leukemia; in vivo;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

We studied the effectiveness of cyclic hydroxamic acid CHA-5 against drug-resistant and multidrug-resistant murine P388 leukemia strains. More than 60% mice receiving transplantation of rubomycin-resistant leukemia P388 strain survived after CHA-5 monotherapy; combined therapy with CHA-5 and cisplatin was also highly effective. Vincristine-resistant tumor was highly sensitive to combined treatment with CHA-5 and cyclophosphamide. It should be emphasized that standard antitumor agents were used in very low doses in combination therapy and CHA-5 significantly potentiated their effect.

引用

页码：385 / 388

页数：3

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