The Effectiveness of Cyclic Hydroxamic Acid CHA-5 against Drug-Resistant P388 Leukemia Strains

被引：0
|
作者：
S. A. Goncharova
I. V. Vystorop
T. A. Raevskaya
N. P. Konovalova
机构：
[1] Russian Academy of Sciences,Institute of Problems of Chemical Physics
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 163卷
关键词：
tumor drug resistance; cyclic hydroxamic acids; murine P388 lymphocytic leukemia; in vivo;
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学科分类号：
摘要：
We studied the effectiveness of cyclic hydroxamic acid CHA-5 against drug-resistant and multidrug-resistant murine P388 leukemia strains. More than 60% mice receiving transplantation of rubomycin-resistant leukemia P388 strain survived after CHA-5 monotherapy; combined therapy with CHA-5 and cisplatin was also highly effective. Vincristine-resistant tumor was highly sensitive to combined treatment with CHA-5 and cyclophosphamide. It should be emphasized that standard antitumor agents were used in very low doses in combination therapy and CHA-5 significantly potentiated their effect.
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页码：385 / 388
页数：3
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