Antitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases

被引:0
|
作者
Wang Liu
Yu Lu
Xiaoping Chai
Xiao Liu
Tong Zhu
Xihan Wu
Yanfen Fang
Xuan Liu
Xiongwen Zhang
机构
[1] East China Normal University,Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering
[2] Nanjing Tianyi Bioscience Co. Ltd,Department of Cardiology, Shanghai Renji Hospital, School of Medicine
[3] Shanghai Jiaotong University,School of Physics and Materials Science
[4] East China Normal University,undefined
关键词
Gastric cancer; Cell cycle; Angiogenesis; Polyploidy; Apoptosis;
D O I
暂无
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [11] A new small-molecule Aurora B inhibitor shows antitumor activity in human cancer cell lines
    Wu, Yuanyuan
    Li, Jie
    Jiang, Chenxiao
    Yang, Xianmei
    Cao, Lihuan
    Yu, Long
    MOLECULAR BIOLOGY REPORTS, 2015, 42 (02) : 517 - 524
  • [12] A new small-molecule Aurora B inhibitor shows antitumor activity in human cancer cell lines
    Yuanyuan Wu
    Jie Li
    Chenxiao Jiang
    Xianmei Yang
    Lihuan Cao
    Long Yu
    Molecular Biology Reports, 2015, 42 : 517 - 524
  • [13] Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells
    Defaux, Julien
    Antoine, Maud
    Loge, Cedric
    Le Borgne, Marc
    Schuster, Tilmann
    Seipelt, Irene
    Aicher, Babette
    Teifel, Michael
    Guenther, Eckhard
    Gerlach, Matthias
    Marchand, Pascal
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (16) : 3748 - 3752
  • [14] Targeting urease to human VEGFR2 elicits antitumor activity in triple-negative breast cancer models
    Muchowicz, Angelika
    Bujak, Anna
    Pyrzynska, Beata
    Karolczak, Justyna
    Zerrouqi, Abdessamad
    Ozga, Magdalena
    Szewczyk, Lukasz
    Tian, Baomin
    Wong, Wah
    Uger, Marni
    Poplawska, Katarzyna
    Gierej, Dorota
    Wisniewski, Pawel
    Chao, Heman
    Winiarska, Magdalena
    Zagozdzon, Radoslaw
    CANCER RESEARCH, 2018, 78 (13)
  • [15] Discovery of AMG 900, a highly selective, orally bioavailable inhibitor of Aurora kinases with efficacy in preclinical antitumor models and activity against multidrug-resistant cancer cell lines
    Geuns-Meyer, Stephanie D.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2014, 248
  • [16] Discovery of AMG 900, a highly selective, orally bioavailable inhibitor of aurora kinases with efficacy in preclinical antitumor models and activity against multidrug-resistant cells
    Geuns-Meyer, Stephanie
    Cee, Victor J.
    Deak, Holly L.
    Du, Bingfan
    Hodous, Brian L.
    Nguyen, Hanh N.
    Olivieri, Philip R.
    Romero, Karina
    Schenkel, Laurie B.
    Patel, Vinod F.
    Be, Xuhai
    Bush, Tammy L.
    Chung, Grace
    Eden, Patrick
    Huang, Liyue
    Kendall, Richard
    Lin, Min-Hwa Jasmine
    Radinsky, Robert
    Ziegler, Beth
    Payton, Marc
    CANCER RESEARCH, 2010, 70
  • [17] A thienopyrimidine derivative induces growth inhibition and apoptosis in human cancer cell lines via inhibiting Aurora B kinase activity
    Li, Jie
    Hu, Hairong
    Lang, Qingyu
    Zhang, Haoxing
    Huang, Qiang
    Wu, Yuanyuan
    Yu, Long
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 65 : 151 - 157
  • [18] The antitumor effect caused by small molecular agents targeting EGFR, VEGFR2 and their downstream kinases in human non small cell lung cancer cells
    Nakachi, Ichiro
    Naoki, Katsuhiko
    Soejima, Kenzo
    Kawada, Ichiro
    Watanabe, Hideo
    Yasuda, Hiroyuki
    Ishizaka, Akitoshi
    JOURNAL OF THORACIC ONCOLOGY, 2007, 2 (08) : S446 - S446
  • [19] Pan-Aurora Kinases and TRAIL Combination Therapy Has Potent Antitumor Activity In Vivo Against Drug-Resistant Human Multiple Myeloma Xenograft Model
    Lunghi, Paolo
    Mazzera, Laura
    Lombardi, Guerino
    Ricca, Micaela
    Abeltino, Manuela
    Arienti, Davide
    Cantoni, Anna Maria
    Corradi, Attilio
    Bonati, Antonio
    BLOOD, 2011, 118 (21) : 804 - 804
  • [20] A hybrid membrane coating nanodrug system against gastric cancer via the VEGFR2/STAT3 signaling pathway
    Long, Ying
    Wang, Zhou
    Fan, Jialong
    Yuan, Liqin
    Tong, Chunyi
    Zhao, Yanzhong
    Liu, Bin
    JOURNAL OF MATERIALS CHEMISTRY B, 2021, 9 (18) : 3838 - 3855