Preparation of a 99mTc-labeled graft polymer and its in vitro and in vivo evaluation

被引：0

作者：

Uğur Avcıbaşı

Taner Türkyarar

Ayşegül Karadağ

Buket Bakan

Nefise Ülkü Karabay Yavaşoğlu

Kevser Kuşat

Sinan Akgöl

Derya Gülcemal

Volkan Tekin

Fazilet Zümrüt Biber Müftüler

Gökcen Topal

Yasemin Parlak

Fikriye Gül Gümüşer

机构：

[1] Manisa Celal Bayar University,Department of Chemistry, Faculty of Art and Science

[2] Ege University,Department of Biology, Faculty of Science

[3] Department of Chemistry,Department of Biochemistry, Faculty of Science

[4] Faculty of Science,Department of Chemistry, Faculty of Science

[5] Dokuz Eylül University,Institute of Nuclear Sciences, Department of Nuclear Applications

[6] Ege University,Department of Nuclear Medicine, School of Medicine

[7] Ege University,Department of Molecular Biology and Genetics, Faculty of Science

[8] Ege University,undefined

[9] Manisa Celal Bayar University,undefined

[10] Atatürk University,undefined

来源：

Journal of Radioanalytical and Nuclear Chemistry | 2021年 / 329卷

关键词：

Nanopolymer; Graft Polymer; Cytotoxicity; Tc; Radiolabeling; Proline;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

The aim of this study is the synthesis of a novel 99mTc-labeld graft polymer and the biological evaluation of its in vitro and in vivo properties. To this end, a L-proline-graft-poly(HEMA) was prepared and labeled with 99mTc. The radiochemical yield of approximately the 99mTc-labeled compound amounted to 97 ± 2.3%. The cytotoxicity test revealed no cytotoxic effect after a 24- and 48-h incubation. The results of the hemolysis test showed that hemolysis was non-toxic with an effect level of less than 2%. Subsequently, the biodistribution in healthy rats was determined. High accumulation of the polymer was observed in the pancreas, thyroid and prostate.

引用

页码：511 / 525

页数：14

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