Thrombin signalling and protease-activated receptors

被引：0
|
作者：
Shaun R. Coughlin
机构：
[1] University of California at San Francisco,Cardiovascular Research Institute and Departments of Medicine and Pharmacology
来源：
Nature | 2000年 / 407卷
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D O I：
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学科分类号：
摘要：
How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.
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页码：258 / 264
页数：6
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