The persistence and fate of fluxapyroxad were investigated including studies with four soils from Hunan (HN), Shanxi (SX), Jiangsu (JS), and Heilongjiang (HLJ) and two water/sediment systems (water/sediment systems 1 and 2) from Beijing, China. The results demonstrated that the biodegradation efficiency of fluxapyroxad in soils under aerobic conditions was higher than that observed under anaerobic conditions. The order of degradation capability was HLJ soil > JS soil > SX soil > HN soil, and fluxapyroxad dissipated faster in water/sediment system 2 than in system 1. The tested systems (four soils and two water/sediments systems) with rich organic matter content, high oxygen level and neutral pH had a high potential to degrade fluxapyroxad, possibly because rich organic matter and oxygen level stimulated microbial activity and the neutral pH was suitable for microbial growth. These results showed that fluxapyroxad exhibited high persistence in tested systems, with half-lives ≥157.6 day.