Nearby luminous galaxies serve as templates to gain insight into the building blocks of the most luminous galaxies in the distant universe. In this conference I have shown that the most luminous galaxies in the Local Universe are mergers of evolved gas-rich galaxies that radiate the bulk of their energy in the mid and far-infrared. The most important implication for future studies on the formation of galaxies at early cosmological timescales is that they will appear as luminous sub-millimeter sources.