PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

被引：0
|
作者：
Seyedmehdi Shojaee
Lai N Chan
Maike Buchner
Valeria Cazzaniga
Kadriye Nehir Cosgun
Huimin Geng
Yi Hua Qiu
Marcus Dühren von Minden
Thomas Ernst
Andreas Hochhaus
Giovanni Cazzaniga
Ari Melnick
Steven M Kornblau
Thomas G Graeber
Hong Wu
Hassan Jumaa
Markus Müschen
机构：
[1] University of California,Department of Laboratory Medicine
[2] San Francisco,Department of Leukemia
[3] Centro Ricerca Tettamanti,Department of Immunology
[4] Clinica Pediatrica,Abteilung Hämatologie
[5] Università di Milano-Bicocca,Onkologie
[6] University of Texas M.D. Anderson Cancer Center,Department of Pharmacology
[7] University of Ulm,Department of Molecular and Medical Pharmacology
[8] Klinik für Innere Medizin II,undefined
[9] Universitätsklinikum Jena,undefined
[10] Weill Cornell Medical College,undefined
[11] University of California,undefined
[12] Los Angeles (UCLA),undefined
来源：
Nature Medicine | 2016年 / 22卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
As opposed to its tumor suppressor role in other cancers, PTEN inhibition in pre-B ALL is therapeutically effective and triggers cell death.
引用
收藏
页码：379 / 387
页数：8
相关论文
共 50 条
  • [21] Ca2+ Oscillations and NFATC1 -Activation Enable Oncogenic Signaling in Pre-B Cell Transformation and Leukemogenesis
    Kume, Kohei
    Chen, Liting
    Lee, Jaewoong
    Muschen, Markus
    BLOOD, 2017, 130
  • [22] Involvement of SLP-65 and Btk in tumor suppression and malignant transformation of pre-B cells
    Hendriks, RW
    Kersseboom, R
    SEMINARS IN IMMUNOLOGY, 2006, 18 (01) : 67 - 76
  • [23] PRE-B AND B CELLS IN RABBITS - ONTOGENY AND ALLELIC EXCLUSION
    HAYWARD, AR
    SIMONS, M
    LAWTON, AR
    COOPER, MD
    MAGE, RG
    FEDERATION PROCEEDINGS, 1977, 36 (03) : 1295 - 1295
  • [24] Understanding how pre-B cells come of age
    Kenneth Dorshkind
    Nature Immunology, 2000, 1 : 369 - 370
  • [25] HYPO-IMMUNOGLOBULINEMIA WITH DEFICIENCY OF PRE-B CELLS
    HAYWARD, AR
    LANCET, 1978, 1 (8072): : 1014 - 1015
  • [26] Understanding how pre-B cells come of age
    Dorshkind, K
    NATURE IMMUNOLOGY, 2000, 1 (05) : 369 - 370
  • [27] ANTIBODY REPERTOIRE EXPRESSED BY ADULT PRE-B CELLS
    BUCKNER, JH
    KANTOR, AB
    HERZENBERG, LA
    MERRILL, CE
    HILLSON, JL
    JOURNAL OF IMMUNOLOGY, 1993, 150 (08): : A259 - A259
  • [28] κ and λ rearrangement occur simultaneously in transformed pre-B cells
    Liu, D
    Jenab, J
    Rosenberg, N
    JOURNAL OF IMMUNOLOGY, 1997, 159 (12): : 6061 - 6069
  • [29] Expression of LECAM-1 and LFA-1 on pre-B lymphoma cells but not on preneoplastic pre-B cells in SL/Kh mice
    Lu, LM
    Ogawa, M
    Kamoto, T
    Yamada, Y
    Pataer, A
    Hiai, H
    LEUKEMIA RESEARCH, 1997, 21 (04) : 337 - 342
  • [30] EARLY PRE-B LYMPHOBLASTIC TRANSFORMATION IN A PATIENT WITH REFRACTORY-ANEMIA
    ROZMAN, M
    RIBERA, JM
    URBANOISPIZUA, A
    MATUTES, E
    VILLAMOR, N
    VIVESCORRONS, JL
    MONTSERRAT, E
    ROZMAN, C
    LEUKEMIA & LYMPHOMA, 1991, 3 (04) : 301 - 303
12345