PTEN opposes negative selection and enables oncogenic transformation of pre-B cells

被引：0

作者：

Seyedmehdi Shojaee

Lai N Chan

Maike Buchner

Valeria Cazzaniga

Kadriye Nehir Cosgun

Huimin Geng

Yi Hua Qiu

Marcus Dühren von Minden

Thomas Ernst

Andreas Hochhaus

Giovanni Cazzaniga

Ari Melnick

Steven M Kornblau

Thomas G Graeber

Hong Wu

Hassan Jumaa

Markus Müschen

机构：

[1] University of California,Department of Laboratory Medicine

[2] San Francisco,Department of Leukemia

[3] Centro Ricerca Tettamanti,Department of Immunology

[4] Clinica Pediatrica,Abteilung Hämatologie

[5] Università di Milano-Bicocca,Onkologie

[6] University of Texas M.D. Anderson Cancer Center,Department of Pharmacology

[7] University of Ulm,Department of Molecular and Medical Pharmacology

[8] Klinik für Innere Medizin II,undefined

[9] Universitätsklinikum Jena,undefined

[10] Weill Cornell Medical College,undefined

[11] University of California,undefined

[12] Los Angeles (UCLA),undefined

来源：

Nature Medicine | 2016年 / 22卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

As opposed to its tumor suppressor role in other cancers, PTEN inhibition in pre-B ALL is therapeutically effective and triggers cell death.

引用

页码：379 / 387

页数：8

共 50 条

[1] PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
Shojaee, Seyedmehdi
Chan, Lai N.
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Cazzaniga, Valeria
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von Minden, Marcus Duehren
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Hochhaus, Andreas
Cazzaniga, Giovanni
Melnick, Ari
Kornblau, Steven M.
Graeber, Thomas G.
Wu, Hong
Jumaa, Hassan
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NATURE MEDICINE, 2016, 22 (04) : 379 - +
[2] PTEN Is Essential for Normal Cytokine Signaling and Oncogenic Transformation of Pre-B Cells
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[3] PTEN enables the development of pre-B acute lymphoblastic leukemia
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[4] PTEN enables the development of pre-B acute lymphoblastic leukemia
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NATURE MEDICINE, 2016, 22 (04) : 339 - 340
[5] Erk Negative Feedback Control Enables Pre-B Cell Transformation and Represents a Therapeutic Target in Acute Lymphoblastic Leukemia
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[6] Pre-b cell receptor-mediated selection of pre-B cells synthesizing functional μ heavy chains
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[7] Secretion of soluble pre-B cell receptors by pre-B cells
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Brewer, JW
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[8] EPSTEIN-BARR VIRUS TRANSFORMATION OF HUMAN PRE-B CELLS
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[9] KLF4 suppresses transformation of pre-B cells by ABL oncogenes
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[10] Pre-B cells can secrete a soluble pre-B receptor complex.
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