Autophagy favors Brucella melitensis survival in infected macrophages

被引：0
|
作者：
Fei Guo
Hui Zhang
Chuangfu Chen
Shengwei Hu
Yuanzhi Wang
Jun Qiao
Yan Ren
Ke Zhang
Yong Wang
Guoqing Du
机构：
[1] Shihezi University,College of Animal Science and Technology
[2] Shihezi University,Key Laboratory of Xijiang Endemic and Ethnic Disease
[3] Shihezi University,College of Medicine
来源：
Cellular & Molecular Biology Letters | 2012年 / 17卷
关键词：
Autophagy; 16M; LC3-II; LC3-I; Autophagosome; Autophagy flux; 3-Methyladenine; Intracellular pathogens; Murine macrophage RAW264.7; Autophagic vesicle;
D O I：
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中图分类号：
学科分类号：
摘要：
This study investigated the role of autophagy in the survival of the invasive bacterium Brucella melitensis strain 16M in murine macrophages. Here, Brucella melitensis 16M was found to trigger autophagosome formation, enhance autophagy flux and increase the expression level of the autophagy marker protein LC3-II. When autophagy was pharmacologically inhibited by 3-methyladenine (3-MA), Brucella replication efficiency was significantly decreased (p < 0.05). These results suggest that autophagy favors Brucella melitensis 16M survival in murine macrophages.
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页码：249 / 257
页数：8
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