Lewis acid catalyzed condensation of 2-aminohetarene N-oxides with N,N-dimethylformamide dimethyl acetal

被引：0
|
作者：
Sergey А. Karalash
Dmitry M. Bystrov
Ivan V. Ananyev
Leonid L. Fershtat
机构：
[1] N. D. Zelinsky Institute of Organic Chemistry,
[2] Russian Academy of Sciences,undefined
[3] Lomonosov Moscow State University,undefined
[4] A. N. Nesmeyanov Institute of Organoelement Compounds,undefined
[5] Russian Academy of Sciences,undefined
来源：
Chemistry of Heterocyclic Compounds | 2021年 / 57卷
关键词：
azines; heterocyclic ; -oxides; Lewis acids; nitrogen-containing heterocycles; pyridines; condensation; protective groups;
D O I：
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学科分类号：
摘要：
A method for the introduction of the N,N-dimethylformamidine protective group in a series of six-membered 2-aminohetarene N-oxides was developed. It was shown that 2-amino derivatives of N-oxides of various six-membered heterocycles (pyridines, pyrimidines, pyrazines, tetrazines) successfully enter the reaction. The stability of the N,N-dimethylformamidine protecting group in 2-aminohetarene N-oxides was found to depend on the type of reaction medium.
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页码：1130 / 1136
页数：6
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