Segmental duplications and the evolution of the primate genome

被引：0
|
作者：
Rhea Vallente Samonte
Evan E. Eichler
机构：
[1] School of Medicine and University Hospitals of Cleveland,Department of Genetics and Center for Human Genetics
[2] Case Western Reserve University,undefined
来源：
Nature Reviews Genetics | 2002年 / 3卷
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摘要：
Initial human genome sequence analysis has revealed large segments of nearly identical sequence in particular chromosomal regions. The recent origin of these segments and their abundance (∼5%) has challenged investigators to elucidate their underlying mechanism and role in primate genome evolution. Although the precise fraction is unknown, some of these duplicated segments have recently been shown to be associated with rapid gene innovation and chromosomal rearrangement in the genomes of man and the great apes.
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页码：65 / 72
页数：7
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