Alkylation of 1-Alkyl-3-methyl-1,4-dihydropyrazolo[4,3-c]pyrazoles with Halocarboxylic Acids Esters

被引:0
|
作者
R. N. Vydzhak
S. Ya. Panchishin
V. S. Brovarets
机构
[1] National Academy of Sciences of Ukraine,Institute of Bioorganic Chemistry and Petrochemistry
来源
关键词
pyrazolo[4,3-; ]pyrazoles; alkylation of pyrazole derivatives; 4-aminopyrazoles; intramolecular cyclocondensation;
D O I
暂无
中图分类号
学科分类号
摘要
A preparative method for the synthesis of 1-alkyl-3-methyl-1,4-dihydropyrazolo[4,3-c]pyrazoles was developed. The alkylation of the obtained compounds with halocarboxylic acid esters was also investigated. A principal possibility of creating libraries of compounds based on pyrazolo[4,3-c]pyrazole derivatives was shown.
引用
收藏
页码:221 / 233
页数:12
相关论文
共 50 条
  • [41] Crystal Structure of 7-Amino-8-R-3-tert-Butyl-4-Oxo-1,4-Dihydropyrazolo[5,1-c][1,2,4]Triazines
    Mironovich, L. M.
    Ivanov, S. M.
    JOURNAL OF APPLIED SPECTROSCOPY, 2021, 88 (03) : 528 - 534
  • [42] Novel alkylations of cyclic thioureas by α-halocarboxylic acids and their esters. 4. Alkylation of 1-methyltetrahydropyrimidine-2(1H)-thione
    Kushakova P.M.
    Basan Yu.V.
    Yulisova A.I.
    Lifontova V.V.
    Ramsh S.M.
    Garabadgiu A.V.
    Belobrzeckaja Costa L.N.
    Chemistry of Heterocyclic Compounds, 2006, 42 (8) : 1078 - 1085
  • [43] A convenient K2CO3 catalysed regioselective synthesis for benzopyrano[4,3-c]pyrazoles in aqueous medium
    Kidwai, Mazaahir
    Priya
    Singhal, Kavita
    Rastogi, Shweta
    HETEROCYCLES, 2007, 71 (03) : 569 - 576
  • [44] Generation and chemical properties of (3,4-di-tert-butyl-1,4-dihydropyrazolo[5,1-c][1,2,4]triazin-4-yl)lithiums
    Ivanov, Sergey M.
    Minyaev, Mikhail E.
    JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2020, 906
  • [45] Thiazolo[4,3-c][1,4]benzodiazepines .2. Synthesis of fused[a]triazolo, tetrazolo and oxadiazolo derivatives
    Gillard, AC
    Rault, S
    Boulouard, M
    Robba, M
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1996, 33 (02) : 275 - 279
  • [46] Synthesis of novel 1,4-dihydropyrido[3′,2′:5,6]thiopyrano[4,3-c]pyrazoles and 5H-pyrido[3′,2′:5,6]thiopyrano[4,3-d]pyrimidines as potential antiproliferative agents
    Primofiore, G
    Marini, AM
    Da Settimo, F
    Salerno, S
    Bertini, D
    Dalla Via, L
    Magno, SM
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2003, 40 (05) : 783 - 788
  • [47] 4-OXO-1H-AND-2H-[1]BENZOPYRANO[4,3-C]PYRAZOLES - PREPARATION FROM 4-HYDROXYCOUMARIN OR 3-CHROMONECARBOXYLIC ACID-DERIVATIVES
    CHANTEGREL, B
    NADI, AI
    GELIN, S
    TETRAHEDRON LETTERS, 1983, 24 (04) : 381 - 384
  • [48] Tricyclic Pyrazoles: Synthesis, Characterization, Antimicrobial, Antituberculosis, and Antitumor Activity of N,1-Dipheny1-1,4-dihydrothiochromeno[4,3-c]pyrazole-3-carboxamide-5,5-dioxide Derivatives
    Palanisamy, Pandaram
    Kumaresan, Sudalaiandi
    BRITISH JOURNAL OF PHARMACEUTICAL RESEARCH, 2014, 4 (14): : 1802 - 1819
  • [49] 2,5-dihydropyrazolo[4,3-c]pyridin-3-ones:: functionally selective benzodiazepine binding site ligands on the GABAA receptor
    Mitchinson, A
    Atack, JR
    Blurton, P
    Carling, RW
    Castro, JL
    Curley, KS
    Russell, MGN
    Marshall, G
    McKernan, RM
    Moore, KW
    Narquizian, R
    Smith, A
    Street, LJ
    Thompson, SA
    Wafford, K
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2004, 14 (13) : 3441 - 3444
  • [50] (8-Chloro-3-methyl-1H-pyrazolo[4,3-c]cinnolin-1-yl) (pyridin-4-yl)methanone
    Bawa, Sandhya
    Kumar, Rajiv
    Chawla, Gita
    Kumar, Suresh
    Mishra, Ravinesh
    MOLBANK, 2010, (02) : 1 - 3