Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration

被引：0
|
作者：
Dorothea Godt
Ulrich Tepass
机构：
[1] University of Toronto,Dorothea Godt and Ulrich Tepass are in the Department of Cell and Systems Biology
[2] Toronto,undefined
[3] Ontario,undefined
[4] M5S 3G5,undefined
[5] Canada. d.godt@utoronto.ca; u.tepass@utoronto.ca,undefined
[6] u.tepass@utoronto.ca,undefined
来源：
Nature Cell Biology | 2009年 / 11卷
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摘要：
Correct timing of developmental events is crucial for generating a normal organism. During oogenesis in Drosophila melanogaster, migration of border cells occurs in a defined temporal window and requires Jak/Stat and steroid hormone signalling. The initiation of border-cell migration is now shown to be timed by Jak/Stat-mediated downregulation of the BTB domain transcriptional regulator Abrupt, which acts as a negative regulator of steroid hormone signalling.
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页码：536 / 538
页数：2
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