Fugitives on the run: circulating tumor cells (CTCs) in metastatic diseases

被引：0
|
作者：
Tania Mamdouhi
Julianne D. Twomey
K. Melodi McSweeney
Baolin Zhang
机构：
[1] Food and Drug Administration,Office of Biotechnology Products, Center for Drug Evaluation and Research
来源：
Cancer and Metastasis Reviews | 2019年 / 38卷
关键词：
Circulating tumor cells; Metastasis; Liquid biopsy; Biomarker;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The presence of circulating tumor cells (CTCs) in the bloodstream signals the existence of a tumor and denotes risk of metastatic spread. CTCs can be isolated and analyzed to monitor cancer progression and therapeutic response. However, CTC isolation devices have shown considerable variation in detection rates, limiting their use as a routine diagnostic and monitoring tool. In this review, we discuss recent advances in CTC detection methodologies and associated clinical studies. We provide perspective on the future direction of CTC isolation and molecular characterization towards developing reliable biomarkers that monitor disease progression or therapeutic response.
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页码：297 / 305
页数：8
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