Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells

被引：0

作者：

Skladanowski A. ^{[1
]}

Konopa J. ^{[1
]}

机构：

[1] Dept. of Pharmaceutical Technol./B., Technical University of Gdan'sk, 80-952 Gdan'sk

来源：

British Journal of Cancer | 2000年 / 82卷 / 7期

关键词：

Aminoanthraquinones; Covalent binding; DNA cross-linking; Mechanism of action; Metabolism; Mitoxantrone;

D O I：

10.1054/bjoc.1999.1095

中图分类号：

学科分类号：

摘要：

We show here that mitoxantrone and ametantrone induce interstrand DNA cross-links in HeLa S3 cells. These cross-links were observed only in cellular system suggesting that metabolism of the drugs is a necessary step leading to DNA cross-linking. Biologically inactive analogue of mitoxantrone, compound NSC 321458, did not induce cross-links in DNA of tumour cells which suggests that DNA crosslinking is associated with the cytotoxic and anti-tumour activity of these compounds. (C) 2000 Cancer Research Campaign.

引用

页码：1300 / 1304

页数：4

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