Mitoxantrone and ametantrone induce interstrand cross-links in DNA of tumour cells

被引：0
|
作者：
Skladanowski A. [1 ]
Konopa J. [1 ]
机构：
[1] Dept. of Pharmaceutical Technol./B., Technical University of Gdan'sk, 80-952 Gdan'sk
来源：
British Journal of Cancer | 2000年 / 82卷 / 7期
关键词：
Aminoanthraquinones; Covalent binding; DNA cross-linking; Mechanism of action; Metabolism; Mitoxantrone;
D O I：
10.1054/bjoc.1999.1095
中图分类号：
学科分类号：
摘要：
We show here that mitoxantrone and ametantrone induce interstrand DNA cross-links in HeLa S3 cells. These cross-links were observed only in cellular system suggesting that metabolism of the drugs is a necessary step leading to DNA cross-linking. Biologically inactive analogue of mitoxantrone, compound NSC 321458, did not induce cross-links in DNA of tumour cells which suggests that DNA crosslinking is associated with the cytotoxic and anti-tumour activity of these compounds. (C) 2000 Cancer Research Campaign.
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页码：1300 / 1304
页数：4
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