A quantitative immunohistochemical study on the time-dependent course of acute inflammatory cellular response to human brain injury

被引：0
|
作者：
R. Hausmann
A. Kaiser
C. Lang
M. Bohnert
P. Betz
机构：
[1] Department of Legal Medicine,
[2] University of Erlangen-Nürnberg,undefined
[3] Universitätsstrasse 22,undefined
[4] D-91054 Erlangen,undefined
[5] Germany,undefined
[6] Institute of Pathology,undefined
[7] Klinikum Nürnberg – Nord,undefined
[8] Flurstrasse 17,undefined
[9] D-90419 Nürnberg,undefined
[10] Germany,undefined
[11] Department of Legal Medicine,undefined
[12] University of Würzburg,undefined
[13] Versbacher Strasse 3,undefined
[14] D-97078 Würzburg,undefined
[15] Germany,undefined
[16] Department of Legal Medicine,undefined
[17] University of Freiburg,undefined
[18] Albertstrasse 9,undefined
[19] D-79104 Freiburg,undefined
[20] Germany,undefined
来源：
International Journal of Legal Medicine | 1999年 / 112卷
关键词：
Key words Brain injury; Cortical contusion; Inflammatory reaction; Immunohistochemistry; Wound; age;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The time-dependent inflammatory cell reaction in human cortical contusions has been investigated during the first 30 weeks after blunt head injury. Immunohistochemical staining was carried out using CD 15 for granulocytes and LCA, CD 3 and UCHL-1 for mononuclear leucocytes. In order to provide reliable data for a forensic wound age estimation, the intensity of the cellular reaction was evaluated with a quantitative image analysis system. CD 15-labelled granulocytes were detectable earliest 10 min after brain injury, whereas significantly increased numbers of mononuclear leucocytes occurred in cortical contusions after a postinfliction interval of at least 1.1 days (LCA), 2 days (CD 3) or 3.7 days (UCHL-1), respectively.
引用
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页码：227 / 232
页数：5
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