The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

被引：0

作者：

Anna K Andersson

Jing Ma

Jianmin Wang

Xiang Chen

Amanda Larson Gedman

Jinjun Dang

Joy Nakitandwe

Linda Holmfeldt

Matthew Parker

John Easton

Robert Huether

Richard Kriwacki

Michael Rusch

Gang Wu

Yongjin Li

Heather Mulder

Susana Raimondi

Stanley Pounds

Guolian Kang

Lei Shi

Jared Becksfort

Pankaj Gupta

Debbie Payne-Turner

Bhavin Vadodaria

Kristy Boggs

Donald Yergeau

Jayanthi Manne

Guangchun Song

Michael Edmonson

Panduka Nagahawatte

Lei Wei

Cheng Cheng

Deqing Pei

Rosemary Sutton

Nicola C Venn

Albert Chetcuti

Amanda Rush

Daniel Catchpoole

Jesper Heldrup

Thoas Fioretos

Charles Lu

Li Ding

Ching-Hon Pui

Sheila Shurtleff

Charles G Mullighan

Elaine R Mardis

Richard K Wilson

Tanja A Gruber

Jinghui Zhang

James R Downing

机构：

[1] St. Jude Children's Research Hospital,Department of Pathology

[2] Lund University,Department of Clinical Genetics

[3] St. Jude Children's Research Hospital,Department of Computational Biology

[4] Pediatric Cancer Genome Project Laboratory,Department of Structural Biology

[5] St. Jude Children's Research Hospital,Department of Biostatistics

[6] St. Jude Children's Research Hospital,Department of Pediatrics

[7] St. Jude Children's Research Hospital,Department of Genetics

[8] Children's Cancer Institute Australia,Department of Oncology

[9] Lowy Cancer Research Centre,undefined

[10] University of New South Wales,undefined

[11] Tumor Bank,undefined

[12] Children's Cancer Research Unit,undefined

[13] Children's Hospital at Westmead,undefined

[14] Skåne University Hospital,undefined

[15] Washington University School of Medicine in St. Louis,undefined

[16] Genome Institute,undefined

[17] Washington University School of Medicine in St. Louis,undefined

[18] St. Jude Children's Research Hospital,undefined

来源：

Nature Genetics | 2015年 / 47卷

关键词：

D O I：

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中图分类号：

学科分类号：

摘要：

Anna Andersson, Tanja Gruber, James Downing and colleagues report a genomic analysis of infant acute lymphoblastic leukemias with MLL rearrangements. They identify recurrent activating mutations in tyrosine kinase, phosphatidylinositol 3-kinase and RAS pathway genes but find that these mutations were often present in minor subclones and lost at the time of relapse.

引用

页码：330 / 337

页数：7

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