Treatment of Genotype 1 HCV Infection in the HIV Coinfected Patient in 2014

被引：0
|
作者：
Cody A. Chastain
Susanna Naggie
机构：
[1] Vanderbilt University Medical Center,Division of Infectious Diseases
[2] Division of Infectious Diseases,undefined
[3] Duke Clinical Research Institute,undefined
来源：
Current HIV/AIDS Reports | 2013年 / 10卷
关键词：
Hepatitis C; HIV; HIV-HCV coinfection; Telaprevir; Boceprevir; Sofosbuvir; Simeprevir; Faldaprevir; Daclatasvir;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hepatitis C (HCV) coinfection is the leading cause of liver-related morbidity and is a leading cause of mortality in human immunodeficiency virus (HIV)-infected individuals in the antiretroviral therapy era. Direct-acting antiviral (DAA) therapies are transforming how HCV is treated with significant improvements in efficacy and tolerability. In this article, DAA agents expected to be available in 2014 are reviewed, including telaprevir, boceprevir, sofosbuvir, simeprevir, faldaprevir, and daclatasvir. Available data regarding clinical efficacy, adverse effects, and drug interactions in HIV-HCV coinfection are discussed. The management of adverse effects of HCV therapy and treatment considerations in patients with cirrhosis are also reviewed.
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页码：408 / 419
页数：11
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