The many faces of nodal and splenic marginal zone lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop

被引:0
|
作者
Alberto Zamò
Michiel van den Brand
Fina Climent
Laurence de Leval
Stefan Dirnhofer
Lorenzo Leoncini
Siok-Bian Ng
Sarah L. Ondrejka
Leticia Quintanilla-Martinez
Lorinda Soma
Andrew Wotherspoon
机构
[1] Institute of Pathology,Department of Pathology
[2] University of Würzburg,Department of Pathology
[3] Pathology-DNA,Department of Laboratory Medicine and Pathology
[4] Location Rijnstate Hospital,Department of Medical Biotechnology, Section of Pathology
[5] Radboud University Medical Center,Department of Pathology, Yong Loo Lin School of Medicine
[6] Hospital Universitari de Bellvitge-IDIBELL,undefined
[7] L’Hospitalet de Llobregat,undefined
[8] Institute of Pathology,undefined
[9] Lausanne University Hospital and Lausanne University,undefined
[10] Institute of Medical Genetics and Pathology,undefined
[11] University Hospital Basel,undefined
[12] University of Basel,undefined
[13] University of Siena,undefined
[14] National University of Singapore,undefined
[15] Cancer Science Institute of Singapore,undefined
[16] National University of Singapore,undefined
[17] Pathology and Laboratory Medicine Institute,undefined
[18] Institute of Pathology and Neuropathology,undefined
[19] Eberhard Karls University of Tübingen and Comprehensive Cancer Center,undefined
[20] University Hospital Tübingen,undefined
[21] Department of Pathology,undefined
[22] City of Hope Medical Center,undefined
[23] Department of Histopathology,undefined
[24] Royal Marsden Hospital,undefined
来源
Virchows Archiv | 2023年 / 483卷
关键词
Marginal zone lymphoma; Splenic marginal zone lymphoma; Splenic diffuse red pulp small B-cell lymphoma; Marginal zone lymphoma transformation; Pediatric nodal marginal zone lymphoma; Pediatric nodal marginal zone hyperplasia;
D O I
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学科分类号
摘要
Session 3 of the lymphoma workshop of the XXI joint meeting of the European Association for Haematopathology and the Society for Hematopathology took place in Florence, Italy, on September 22, 2022. The topics of this session were splenic and nodal marginal zone lymphomas, transformation in marginal zone lymphomas, and pediatric nodal marginal zone lymphomas and their differential diagnosis as well as related entities. Forty-two cases in these categories were submitted to the workshop, including splenic lymphomas (marginal zone and diffuse red pulp lymphomas), transformed marginal zone lymphomas (splenic and nodal), nodal marginal zone lymphomas with increased TFH-cells, and pediatric nodal marginal zone lymphomas. The case review highlighted some of the principal problems in the diagnosis of marginal zone lymphomas, including the difficulties in the distinction between splenic marginal zone lymphoma, splenic diffuse red pulp lymphoma, and hairy cell leukemia variant/splenic B-cell lymphoma with prominent nucleoli which requires integration of clinical features, immunophenotype, and morphology in blood, bone marrow, and spleen; cases of marginal zone lymphoma with markedly increased TFH-cells, simulating a T-cell lymphoma, where molecular studies (clonality and mutation detection) can help to establish the final diagnosis; the criteria for transformation of marginal zone lymphomas, which are still unclear and might require the integration of morphological and molecular data; the concept of an overlapping spectrum between pediatric nodal marginal zone lymphoma and pediatric-type follicular lymphoma; and the distinction between pediatric nodal marginal zone lymphoma and “atypical” marginal zone hyperplasia, where molecular studies are mandatory to correctly classify cases.
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页码:317 / 331
页数:14
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