Although bacteria are known to have an important role in Crohn's disease, no specific groups or a single bacterium have been definitively associated with the initiation of this disease. This Review presents advances in understanding the role of bacteria and the contribution of pattern-recognition receptors and autophagy in the pathogenesis of Crohn's disease.
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Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Unit Crit Care Med, London SW3 6LY, EnglandUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Unit Crit Care Med, London SW3 6LY, England
Mitchell, J. A.
Ryffel, B.
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Univ Orleans, F-45071 Orleans, France
CNRS, Mol Immunol & Embryol IEM, F-45071 Orleans, France
Key Obs R&D, F-45100 Orleans, FranceUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Unit Crit Care Med, London SW3 6LY, England
Ryffel, B.
Quesniaux, V. F. J.
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Univ Orleans, F-45071 Orleans, France
CNRS, Mol Immunol & Embryol IEM, F-45071 Orleans, FranceUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Unit Crit Care Med, London SW3 6LY, England
Quesniaux, V. F. J.
Cartwright, N.
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Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Unit Crit Care Med, London SW3 6LY, EnglandUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Unit Crit Care Med, London SW3 6LY, England
Cartwright, N.
Paul-Clark, M.
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Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Unit Crit Care Med, London SW3 6LY, EnglandUniv London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Unit Crit Care Med, London SW3 6LY, England