Insights into the origin of the nuclear localization signals in conserved ribosomal proteins

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作者：
Sergey Melnikov
Adam Ben-Shem
Gulnara Yusupova
Marat Yusupov
机构：
[1] Strasbourg University,Department of Molecular Biophysics and Biochemistry
[2] Institute of Genetics and Molecular and Cellular Biology,undefined
[3] Yale University,undefined
[4] CNRS,undefined
[5] 1 Rue Laurent Fries,undefined
来源：
Nature Communications | / 6卷
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摘要：
Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodelling of their RNA-binding domains. This finding enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.
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