Insights into the origin of the nuclear localization signals in conserved ribosomal proteins

被引：0
|
作者：
Sergey Melnikov
Adam Ben-Shem
Gulnara Yusupova
Marat Yusupov
机构：
[1] Strasbourg University,Department of Molecular Biophysics and Biochemistry
[2] Institute of Genetics and Molecular and Cellular Biology,undefined
[3] Yale University,undefined
[4] CNRS,undefined
[5] 1 Rue Laurent Fries,undefined
来源：
Nature Communications | / 6卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Eukaryotic ribosomal proteins, unlike their bacterial homologues, possess nuclear localization signals (NLSs) to enter the cell nucleus during ribosome assembly. Here we provide a comprehensive comparison of bacterial and eukaryotic ribosomes to show that NLSs appear in conserved ribosomal proteins via remodelling of their RNA-binding domains. This finding enabled us to identify previously unknown NLSs in ribosomal proteins from humans, and suggests that, apart from promoting protein transport, NLSs may facilitate folding of ribosomal RNA.
引用
收藏
相关论文
共 50 条
  • [1] Insights into the origin of the nuclear localization signals in conserved ribosomal proteins
    Melnikov, Sergey
    Ben-Shem, Adam
    Yusupova, Gulnara
    Yusupov, Marat
    NATURE COMMUNICATIONS, 2015, 6
  • [2] Origin of the nuclear proteome on the basis of pre-existing nuclear localization signals in prokaryotic proteins
    Lisitsyna, Olga M.
    Kurnaeva, Margarita A.
    Arifulin, Eugene A.
    Shubina, Maria Y.
    Musinova, Yana R.
    Mironov, Andrey A.
    Sheval, Eugene, V
    BIOLOGY DIRECT, 2020, 15 (01)
  • [3] Origin of the nuclear proteome on the basis of pre-existing nuclear localization signals in prokaryotic proteins
    Olga M. Lisitsyna
    Margarita A. Kurnaeva
    Eugene A. Arifulin
    Maria Y. Shubina
    Yana R. Musinova
    Andrey A. Mironov
    Eugene V. Sheval
    Biology Direct, 15
  • [4] Nuclear localization signals in trypanosomal proteins
    Canela-Perez, Israel
    Lopez-Villasenor, Imelda
    Mendoza, Luis
    Maria Cevallos, Ana
    Hernandez, Roberto
    MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 2019, 229 : 15 - 23
  • [5] Two nuclear localization signals required for the nuclear localization of rice ribosomal protein S4
    Yi, L
    Qu, LJ
    Chang, SR
    Su, YJ
    Gu, HY
    Chen, ZL
    PLANT SCIENCE, 2002, 162 (02) : 251 - 256
  • [6] Nuclear import of ribosomal proteins:: Evidence for a novel type of nuclear localization signal
    Stuger, R
    Timmers, ACJ
    Raué, HA
    van't Riet, J
    RIBOSOME: STRUCTURE, FUNCTION, ANTIBIOTICS, AND CELLULAR INTERACTIONS, 2000, : 205 - 214
  • [7] Archaeal Ribosomal Proteins Possess Nuclear Localization Signal-Type Motifs: Implications for the Origin of the Cell Nucleus
    Melnikov, Sergey
    Kwok, Hui-Si
    Manakongtreecheep, Kasidet
    van den Elzen, Antonia
    Thoreen, Carson C.
    Soll, Dieter
    MOLECULAR BIOLOGY AND EVOLUTION, 2020, 37 (01) : 124 - 133
  • [8] New insights into the nuclear localization of retroviral Gag proteins
    Parent, Leslie J.
    NUCLEUS, 2011, 2 (02) : 92 - 97
  • [9] Charge versus sequence for nuclear/nucleolar localization of plant ribosomal proteins
    Savada, Raghavendra P.
    Bonham-Smith, Peta C.
    PLANT MOLECULAR BIOLOGY, 2013, 81 (4-5) : 477 - 493
  • [10] Charge versus sequence for nuclear/nucleolar localization of plant ribosomal proteins
    Raghavendra P. Savada
    Peta C. Bonham-Smith
    Plant Molecular Biology, 2013, 81 : 477 - 493
12345