A novel one-pot synthesis method of 3,4,5-triaryl-substituted 1,2,4-triazoles

被引：0
|
作者：
Igor K. Yakuschenko
Natal’ya N. Pozdeeva
Svyatoslav Ya. Gadomsky
机构：
[1] Institute of Problems of Chemical Physics of the Russian Academy of Sciences,
来源：
Chemistry of Heterocyclic Compounds | 2019年 / 55卷
关键词：
hydrazides; polyphosphoric ester; secondary amides; 3,4,5-substituted 1,2,4-triazoles; one-pot synthesis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
A novel method for the preparation of 3,4,5-triaryl-substituted 1,2,4-triazoles by the reaction of hydrazides with secondary amides in polyphosphoric ester has been developed. The new method is characterized by mild conditions and ease of synthesis, including the stages of isolation and purification of the product. Additionally, product structures were confirmed by counter synthesis. It was shown that the proposed method is suitable for producing 1,2,4-triazoles with phenolic substituents without the stages of the protection and deprotection of the hydroxyl group. Using the new method, five 3,4,5-substituted 1,2,4-triazoles were obtained for the first time.
引用
收藏
页码：834 / 838
页数：4
相关论文
共 50 条
  • [1] A novel one-pot synthesis method of 3,4,5-triaryl-substituted 1,2,4-triazoles
    Yakuschenko, Igor K.
    Pozdeeva, Natal'ya N.
    Gadomsky, Svyatoslav Ya
    [J]. CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2019, 55 (09) : 834 - 838
  • [2] Efficient and regiospecific one-pot synthesis of substituted 1,2,4-triazoles
    Stocks, MJ
    Cheshire, DR
    Reynolds, R
    [J]. ORGANIC LETTERS, 2004, 6 (17) : 2969 - 2971
  • [3] Microwave-assisted and efficient one-pot synthesis of substituted 1,2,4-triazoles
    Li, DL
    Bao, HL
    You, TP
    [J]. HETEROCYCLES, 2005, 65 (08) : 1957 - 1962
  • [4] Synthesis and antitumor activity of 3,4,5-substituted 1,2,4-triazoles
    T. R. Ovsepyan
    R. G. Melik-Ogandzhanyan
    G. A. Panosyan
    F. G. Arsenyan
    B. T. Garibdzhanyan
    [J]. Pharmaceutical Chemistry Journal, 2009, 43 : 645 - 648
  • [5] One-pot synthesis of 3,4,5-trisubstituted 1,2,4-triazoles via the addition of hydrazides to activated secondary amides
    Bechara, William
    Khazhieva, Inna
    Rodriguez, Elsa
    Charette, Andre
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 250
  • [6] One-Pot Synthesis of 3,4,5-Trisubstituted 1,2,4-Triazoles via the Addition of Hydrazides to Activated Secondary Amides
    Bechara, William S.
    Khazhieva, Inna S.
    Rodriguez, Elsa
    Charette, Andre B.
    [J]. ORGANIC LETTERS, 2015, 17 (05) : 1184 - 1187
  • [7] One-pot parallel synthesis of 1,3,5-trisubstituted 1,2,4-triazoles
    Dmytro S. Radchenko
    Vasyl S. Naumchyk
    Igor Dziuba
    Andrii A. Kyrylchuk
    Kateryna E. Gubina
    Yurii S. Moroz
    Oleksandr O. Grygorenko
    [J]. Molecular Diversity, 2022, 26 : 993 - 1004
  • [8] One-pot parallel synthesis of 1,3,5-trisubstituted 1,2,4-triazoles
    Radchenko, Dmytro S.
    Naumchyk, Vasyl S.
    Dziuba, Igor
    Kyrylchuk, Andrii A.
    Gubina, Kateryna E.
    Moroz, Yurii S.
    Grygorenko, Oleksandr O.
    [J]. MOLECULAR DIVERSITY, 2022, 26 (02) : 993 - 1004
  • [9] A Novel Iron-catalyzed One-pot Synthesis of 3-Amino-1,2,4-triazoles
    Rohand, Taoufik
    Mkpenie, Victor N.
    El Haddad, Mohammadine
    Marko, Istvan E.
    [J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2019, 56 (02) : 690 - 695
  • [10] Facile One-Pot Parallel Synthesis of 3-Amino-1,2,4-triazoles
    Bogolyubsky, Andrey, V
    Savych, Olena
    Zhemera, Anton, V
    Pipko, Sergey E.
    Grishchenko, Alexander, V
    Konovets, Anzhelika, I
    Doroshchuk, Roman O.
    Khomenko, Dmytro N.
    Brovarets, Volodymyr S.
    Moroz, Yurii S.
    Vybornyi, Mykhailo
    [J]. ACS COMBINATORIAL SCIENCE, 2018, 20 (07) : 461 - 466
12345